PIRIDOCAINE

US Previously Marketed

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H20N2O2
Molecular Weight	248.3208
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=C(C=CC=C1)C(=O)OCCC2CCCCN2

InChI

InChIKey=BMIJYAZXNZEMLI-UHFFFAOYSA-N

InChI=1S/C14H20N2O2/c15-13-7-2-1-6-12(13)14(17)18-10-8-11-5-3-4-9-16-11/h1-2,6-7,11,16H,3-5,8-10,15H2

HIDE SMILES / InChI

Molecular Formula	C14H20N2O2
Molecular Weight	248.3208
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14790300 | https://www.ncbi.nlm.nih.gov/pubmed/13283354 | https://www.ncbi.nlm.nih.gov/pubmed/14474052

Piridocaine is a piperidyl propanol ester of orthoaminobenzoic acid. The toxicity of this drug resembles that of procaine. It differs from procaine in that the minimum anesthetic dose is smaller, the minimal lethal dose larger, and duration of anesthesia longer. Subarachnoid piridocaine with and without epinephrine or ephedrine offers a simple and dependable means of obtaining any degree or extent of analgesia up to the third thoracic nerves without profound or widespread motor paralysis. The most promising clinical field of usefulness for piridocaine is obstetrics.

Originator

Approval Year

Sourcing

Vendor/Aggregator	ID	URL
AAA Chemistry	AR-1L1140
ABI Chem	AC1L1NHY
ABI Chem	AC1Q66S7
AbovChem LLC	HY-U00109
BOC Sciences	87-21-8
ChemMol	99171463	http://www.chemmol.com/chemmol/99171463.html
Chemieliva Pharmaceutical Co., Ltd	PBCM1444908
NovoSeek	6875
THE BioTek	bt-401819	https://www.thebiotek.com/product/others/bt-401819
ZINC	ZINC000000000638	http://zinc15.docking.org/substances/ZINC000000000638
ZINC	ZINC000001996127	http://zinc15.docking.org/substances/ZINC000001996127
eMolecules	232694332

PubMed

Title	Date	PubMed
Lucaine as a spinal anesthetic agent for urological surgery.	1948 Nov	18891498
Obstetric saddle block anesthesia with lucaine hydrochloride.	1950 Feb	15409564
The use of lucaine in the study of spinal anesthesia.	1950 Nov	14790300
Anesthesia for anorectal surgery; discussion of experiences with lucaine hydrochloride.	1952 Dec	12996682
Lucaine hydrochloride for obstetrical spinal analgesia; preliminary report.	1952 Feb	14908457
Spinal analgesia with piridocaine hydrochloride for cesarean and vaginal deliveries.	1955 Jan	13238156
Spinal anesthesia with piridocaine (lucaine) further investigations and refinements of technic.	1955 May	14368202
Spinal analgesia with lucaine: a critical appraisal based on 6,000 cases.	1956 Jan	13283354
Lucaine for obstetric anesthesia.	1962 May-Jun	14474052

Sample Use Guides

In Vivo Use Guide

Single dose - 30 mg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:52:58 GMT 2023` Edited by `admin` on `Sat Dec 16 17:52:58 GMT 2023`
Record UNII	488S0H4SQF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PIRIDOCAINE

Official Name

English

PIRIDOCAINE [MI]

Common Name

English

PD-14

Code

English

2-PIPERIDINEETHANOL ANTHRANILATE

Systematic Name

English

LUCAINE

Common Name

English

PIPERIDINEETHANOL ANTHRANILATE

Systematic Name

English

2-PIPERIDINEETHANOL, 2-(2-AMINOBENZOATE)

Systematic Name

English

PT-14

Code

English

.BETA.-(2-PIPERIDYL)ETHYL O-AMINOBENZOATE

Common Name

English

piridocaine [INN]

Common Name

English

ANTHRANILIC ACID 2-(2-PIPERIDYL)ETHYL ESTER

Systematic Name

English

2-PIPERIDINEETHANOL 2-AMINOBENZOATE (ESTER)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C245