BIFLURANOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H18F2O2
Molecular Weight	292.3204
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H]([C@H](C)C1=CC(F)=C(O)C=C1)C2=CC=C(O)C(F)=C2

InChI

InChIKey=RDVXUHOSYIBGBT-ZWNOBZJWSA-N

InChI=1S/C17H18F2O2/c1-3-13(12-5-7-17(21)15(19)9-12)10(2)11-4-6-16(20)14(18)8-11/h4-10,13,20-21H,3H2,1-2H3/t10-,13-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H18F2O2
Molecular Weight	292.3204
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://doi.org/10.1002/pros.2990070403 | https://www.ncbi.nlm.nih.gov/pubmed/2559252

Bifluranol (brand name Prostarex), a fluorinated bibenzyl anti-androgen was developed as a nonsteroidal estrogen and was studied for the treatment of benign prostatic hyperplasia. Besides, was shown that bifluranol inhibited 17 alpha-hydroxylase/C17-C20 lyase.

Approval Year

PubMed

Title	Date	PubMed
Comparison of the novel bibenzyl bifluranol with diethystilboestrol: effect of aromatic fluorine substitution on metabolism [proceedings].	1978 Jun	667433
Anti-prostatic activity of bifluranol, a fluorinated bibenzyl.	1980	6258683
Bifluranol, a novel fluorinated bibenzyl anti-androgen, its chemistry and disposition in different animal species.	1981 May	6116777

Sample Use Guides

In Vivo Use Guide

Thirty five patients with bladder outflow obstruction received either Bifluranol 1.5 mg orally, t.d.s. or placebo in a double‐blind trial.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:35:14 GMT 2023` Edited by `admin` on `Fri Dec 15 15:35:14 GMT 2023`
Record UNII	47602X79JF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BIFLURANOL

Official Name

English

BX 341

Code

English

BX-341

Code

English

BIFLURANOL [MI]

Common Name

English

bifluranol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C242