ALBUTOIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H16N2OS
Molecular Weight	212.312
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CC1NC(=S)N(CC=C)C1=O

InChI

InChIKey=RATGSRSDPNECNO-UHFFFAOYSA-N

InChI=1S/C10H16N2OS/c1-4-5-12-9(13)8(6-7(2)3)11-10(12)14/h4,7-8H,1,5-6H2,2-3H3,(H,11,14)

HIDE SMILES / InChI

Molecular Formula	C10H16N2OS
Molecular Weight	212.312
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4206927 | https://www.drugfuture.com/chemdata/albutoin.html | https://www.ncbi.nlm.nih.gov/pubmed/19298435

Albutoin has been shown to have an anticonvulsant activity against clonic and tonic experimental seizures in mice and rats, particularly those induced by pentylenetetrazol. The first report, in 1959, of the clinical use of albutoin indicated that the drug was more effective in tonic-clonic seizures than in absence seizures. Albutoin was marketed in Europe as CO-ORD and Euprax by Baxter Laboratories. Albutoin was not approved by the United States Food and Drug Administration.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacologic interactions of albutoin with other anticonvulsant drugs.	1970 Aug	5451364
Evaluation of albutoin as an antiepileptic drug.	1974 Apr	4206927
Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.	2009 Mar	19298435

Sample Use Guides

In Vivo Use Guide

The low dosage of albutoin (600 mg/day, medication schedule 2) was not more effective than placebo (medication schedule 1) in preventing excess seizures. The high dosage of albutoin (1,200 mg/day, medication schedule 3) had about the same effectiveness as the low dosage of phenobarbital (150 mg/day, medication schedule 4) in preventing excess seizures.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:54:41 GMT 2023` Edited by `admin` on `Sat Dec 16 16:54:41 GMT 2023`
Record UNII	475NGR2DC1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALBUTOIN

Official Name

English

ALBUTOIN [MART.]

Common Name

English

(±)-4-IMIDAZOLIDINONE, 5-(2-METHYLPROPYL)-3-(2-PROPENYL)-2-THIOXO-

Systematic Name

English

4-IMIDAZOLIDINONE, 5-(2-METHYLPROPYL)-3-(2-PROPENYL)-2-THIOXO-

Systematic Name

English

Albutoin [WHO-DD]

Common Name

English

ALBUTOIN [MI]

Common Name

English

BAX-422Z

Code

English

ALBUTOIN [USAN]

Common Name

English

3-Allyl-5-isobutyl-2-thiohydantoin

Systematic Name

English

EUPRAX

Brand Name

English

albutoin [INN]

Common Name

English

(±)-3-ALLYL-5-ISOBUTYL-2-THIOHYDANTOIN

Systematic Name

English

BAX 422Z

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C264