U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C15H27N3O4S2
Molecular Weight 377.523
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RISOTILIDE

SMILES

CC(C)NCCN(C(C)C)S(=O)(=O)C1=CC=C(NS(C)(=O)=O)C=C1

InChI

InChIKey=GLIRXHQYWRYQDV-UHFFFAOYSA-N
InChI=1S/C15H27N3O4S2/c1-12(2)16-10-11-18(13(3)4)24(21,22)15-8-6-14(7-9-15)17-23(5,19)20/h6-9,12-13,16-17H,10-11H2,1-5H3

HIDE SMILES / InChI

Molecular Formula C15H27N3O4S2
Molecular Weight 377.523
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Risotilide is a Class III antiarrhythmic agent that inhibits the voltage-dependent potassium channel. Risotilide prolongs cardiac action potentials and refractory periods. It was shown to reduce ventricular vulnerability in a study on arrhythmogenic effects of left ventricular hypertrophy (LVH) in the intact heart in cats. Phase I and II trials have been conducted, but development of this drug has been discontinued.

Originator

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 18:55:26 GMT 2023
Edited
by admin
on Fri Dec 15 18:55:26 GMT 2023
Record UNII
46Z36VJE7H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RISOTILIDE
INN  
INN  
Official Name English
risotilide [INN]
Common Name English
4'-(ISOPROPYL(2-(ISOPROPYLAMINO)ETHYL)SULFAMOYL)METHANESULFONANILIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C47793
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C152230
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EPA CompTox
DTXSID90152966
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
CAS
120688-08-6
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110984
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
SMS_ID
100000080591
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
MESH
C063978
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
FDA UNII
46Z36VJE7H
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
PUBCHEM
60667
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
INN
6531
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
EVMPD
SUB10333MIG
Created by admin on Fri Dec 15 18:55:27 GMT 2023 , Edited by admin on Fri Dec 15 18:55:27 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY