DETROTHYRONINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C15H12I3NO4
Molecular Weight	650.9735
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N[C@H](CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1)C(O)=O

InChI

InChIKey=AUYYCJSJGJYCDS-GFCCVEGCSA-N

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C15H12I3NO4
Molecular Weight	650.9735
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: Martindale, W. (1993) The Extra Pharmacopoeia, page 988, retrieved from: https://books.google.ru/books?id=EGZWAAAAYAAJ | Martindale, W. (1967) The Extra Pharmacopoeia, page 1427, retrieved from: https://books.google.ru/books?id=xH-4AAAAIAAJ | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 95, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Detrothyronine is the (R)-(D)-form of triiodothyronine and has antihyperlipidaemic actions with beneficial effects upon coronary disease and hypertension. Detrothyronine has been tried in the treatment of hypercholesterolemia but its toxic effects outweigh any therapeutic advantage.

Approval Year

Sample Use Guides

In Vivo Use Guide

1.5 to 2 mg daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:52:13 UTC 2023` Edited by `admin` on `Sat Dec 16 16:52:13 UTC 2023`
Record UNII	46XII7C16X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DETROTHYRONINE

Official Name

English

D-3-(4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL)-ALANINE

Common Name

English

ALANINE, 3-(4-(4-HYDROXY-3-IODOPHENOXY)-3,5-DIIODOPHENYL)-, D-

Systematic Name

English

DETROTHYRONINE [MART.]

Common Name

English

D-TYROSINE, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-

Systematic Name

English

RATHYRONINE, (R)-

Common Name

English

NSC-46046

Code

English

(+)-TRIIODOTHYRONINE

Systematic Name

English

detrothyronine [INN]

Common Name

English

DT-3

Code

English

3,3',5-TRIIODO-D-THYRONINE

Systematic Name

English

DEXTROTHYRONINE

Common Name

English

Code System Code Type Description

INN

1008