A-331440

CN(C)[C@@H]1CCN(CCCOC2=CC=C(C=C2)C3=CC=C(C=C3)C#N)C1

InChIKey=FXIPXWLVYIHFEP-OAQYLSRUSA-N

InChI=1S/C22H27N3O/c1-24(2)21-12-14-25(17-21)13-3-15-26-22-10-8-20(9-11-22)19-6-4-18(16-23)5-7-19/h4-11,21H,3,12-15,17H2,1-2H3/t21-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H3 receptor 46 Target ID: CHEMBL264 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15447739	Antagonist 2849		22.7 nM [Ki]

PubMed

Title	Date	PubMed
Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist.	2011-07-14	21634396
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist.	2004-03-08	15033391

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:10:51 GMT 2025` Edited by `admin` on `Mon Mar 31 22:10:51 GMT 2025`
Record UNII	45WZM2FLYQ
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

(1,1'-BIPHENYL)-4-CARBONITRILE, 4'-(3-((3R)-3-(DIMETHYLAMINO)-1-PYRROLIDINYL)PROPOXY)-

Preferred Name

English

A-331440

Common Name

English

4'-(3-((3R)-3-(DIMETHYLAMINO)PYRROLIDINYL)PROPOXY)(1,1'-BIPHENYL)-4-CARBONITRILE

Systematic Name

English

Code System Code Type Description

FDA UNII

45WZM2FLYQ

Created by admin on Mon Mar 31 22:10:51 GMT 2025 , Edited by admin on Mon Mar 31 22:10:51 GMT 2025

PRIMARY

PUBCHEM

9884746

Created by admin on Mon Mar 31 22:10:51 GMT 2025 , Edited by admin on Mon Mar 31 22:10:51 GMT 2025

PRIMARY

CAS

392338-13-5

Created by admin on Mon Mar 31 22:10:51 GMT 2025 , Edited by admin on Mon Mar 31 22:10:51 GMT 2025

PRIMARY

Related Record Type Details


					45WZM2FLYQ

A-331440

ACTIVE MOIETY