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Details

Stereochemistry ACHIRAL
Molecular Formula CO3.2Na
Molecular Weight 105.9884
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM CARBONATE

SMILES

[Na+].[Na+].[O-]C([O-])=O

InChI

InChIKey=CDBYLPFSWZWCQE-UHFFFAOYSA-L
InChI=1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula CO3
Molecular Weight 60.0089
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Potash (Dihydroxyaluminum Sodium Carbonate), a component of Kompensan-S Forte in Germany, is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Kompensan-S Forte is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins.

Originator

Pfizer
407
Curator's Comment: # Pfizer

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8228
Inhibitor
8228
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8360
Kompensan

Approved Use

Gastrointestinal disorders: Dyspepsia, Duodenal Ulcer, Erosive Esophagitis, Gastric Ulcer, Gastroesophageal Reflux Disease, Zollinger-Ellison Syndrome, Hyperphosphatemia
PubMed

PubMed

TitleDatePubMed
Effect of pepsin on the kinetics of HCl neutralization by dihydroxyaluminum sodium carbonate, hydrotalcite and dihydroxyaluminum aminoacetate.
1991
Patents

Patents

03994954
10
04584077
9
05739318
9
06555570
10
08404650
9
20120045381
9
US2783124
6
US4438085
6

Sample Use Guides

In Vivo Use Guide
Usual Adult Dose for Dyspepsia: 500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Duodenal Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Erosive Esophagitis: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastric Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Gastroesophageal Reflux Disease: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Zollinger-Ellison Syndrome: 500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime. Usual Adult Dose for Hyperphosphatemia: 500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:03:20 UTC 2023
Edited
by admin
on Thu Jul 06 00:03:20 UTC 2023
Record UNII
45P3261C7T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM CARBONATE
FCC   HSDB   II   INCI   MART.   MI   ORANGE BOOK   VANDF  
INCI  
Official Name English
SODIUM CARBONATE [INCI]
Common Name English
SODIUM CARBONATE [ORANGE BOOK]
Common Name English
NATRUM CARBONICUM
HPUS  
Common Name English
NSC-156204
Code English
SODIUM CARBONATE (ANHYDROUS)
Common Name English
INS NO.500(I)
Code English
SODIUM CARBONATE [II]
Common Name English
SODIUM SALT OF CARBONIC ACID
Common Name English
CARBONIC ACID, DISODIUM SALT
Common Name English
SOLVAY SODA
Common Name English
CARBONIC ACID SODIUM SALT (1:2)
Common Name English
SODA ASH [II]
Common Name English
SODIUM CARBONATE ANHYDROUS [MART.]
Common Name English
SODIUM CARBONATE, ANHYDROUS
EP  
Common Name English
SODA ASH
II  
Common Name English
SODIUM CARBONATE [MI]
Common Name English
Sodium carbonate anhydrous [WHO-DD]
Common Name English
DRIED SODIUM CARBONATE [JAN]
Common Name English
SODIUM CARBONATE ANHYDROUS [USP-RS]
Common Name English
Disodium carbonate
Systematic Name English
SODIUM CARBONATE, ANHYDROUS [EP IMPURITY]
Common Name English
NATRUM CARBONICUM [HPUS]
Common Name English
SODIUM CARBONATE [FCC]
Common Name English
SODIUM CARBONATE [HSDB]
Common Name English
INS-500(I)
Code English
SODIUM CARBONATE [EP MONOGRAPH]
Common Name English
SODIUM CARBONATE [MART.]
Common Name English
SODA-ASH
Common Name English
SODIUM CARBONATE ANHYDROUS
MART.   USP-RS   WHO-DD  
Common Name English
E-500(I)
Code English
ANHYDROUS SODIUM CARBONATE
Common Name English
SODIUM CARBONATE [VANDF]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-500(I)
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
DSLD 2044 (Number of products:3)
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
CFR 21 CFR 184.1742
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
CFR 21 CFR 331.15
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
EPA PESTICIDE CODE 73506
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
NCI_THESAURUS C29730
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
WHO-ATC A02AB04
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
JECFA EVALUATION INS-500(I)
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
CFR 21 CFR 331.11
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
Code System Code Type Description
FDA UNII
45P3261C7T
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
CAS
497-19-8
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
RXCUI
36685
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY RxNorm
PUBCHEM
10340
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
RS_ITEM_NUM
1613757
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
DAILYMED
45P3261C7T
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
HSDB
5018
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
ECHA (EC/EINECS)
207-838-8
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
MESH
C005686
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
SMS_ID
100000078105
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
EPA CompTox
DTXSID1029621
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
MERCK INDEX
M10001
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C47721
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
JECFA MONOGRAPH
INS-500(I)
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
DRUG CENTRAL
5132
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
ChEMBL
CHEMBL186314
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
EVMPD
SUB12580MIG
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
NSC
156204
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
WIKIPEDIA
SODIUM CARBONATE
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
CHEBI
29377
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
EVMPD
SUB15279MIG
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
DRUG BANK
DB09460
Created by admin on Thu Jul 06 00:03:20 UTC 2023 , Edited by admin on Thu Jul 06 00:03:20 UTC 2023
PRIMARY
Related Record Type Details
Structure of SODIUM CARBONATE DECAHYDRATE
SOLVATE->ANHYDROUS
Related Record Type Details
Structure of CARBONATE ION
ACTIVE MOIETY
NIH
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