GEMEPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H38O5
Molecular Weight	394.5448
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(=O)OC

InChI

InChIKey=KYBOHGVERHWSSV-VNIVIJDLSA-N

InChI=1S/C23H38O5/c1-5-6-15-23(2,3)21(26)14-13-18-17(19(24)16-20(18)25)11-9-7-8-10-12-22(27)28-4/h10,12-14,17-18,20-21,25-26H,5-9,11,15-16H2,1-4H3/b12-10+,14-13+/t17-,18-,20-,21-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H38O5
Molecular Weight	394.5448
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	2
Optical Activity	UNSPECIFIED

Description
Sources: https://gp2u.com.au/static/pdf/C/CERVAGEM-PI.pdf

Gemeprost is a PGE1 analogue indicated for softening and dilatation of the cervix uteri prior to operative procedures or therapeutic abortion. The drug is marketed under the name Cervagem.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
uterine smooth muscle contraction 3 Target ID: GO:0070471 Sources: https://www.medicines.org.uk/emc/medicine/3968	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cervical dilatation 1 Sources: https://gp2u.com.au/static/pdf/C/CERVAGEM-PI.pdf	Primary		Approved 8429	CERVAGEM Approved Use For the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy. Therapeutic termination of pregnancy in patients in the second trimester of gestation. Launch Date 1990

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

One pessary to be inserted into the posterior vaginal fornix three hours before surgery.

Route of Administration: Vaginal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:12 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:12 GMT 2023`
Record UNII	45KZB1FOLS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GEMEPROST

Official Name

English

PREGLANDIN

Brand Name

English

Methyl (E)-7-[(1R,2R,3R)-3-hydroxy-2-[(E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-5-oxocyclopentyl]-2-heptenoate

Systematic Name

English

GEMEPROST [MART.]

Common Name

English

gemeprost [INN]

Common Name

English

GEMEPROST [USAN]

Common Name

English

Gemeprost [WHO-DD]

Common Name

English

GEMEPROST [JAN]

Common Name

English

GEMEPROST [MI]

Common Name

English

PROSTA-2,13-DIEN-1-OIC ACID, 11,15-DIHYDROXY-16,16-DIMETHYL-9-OXO-, METHYL ESTER, (2E,11.ALPHA.,13E,15R)-

Common Name

English

SC-37681

Code

English

U-37026

Common Name

English

Classification Tree Code System Code

WHO-ATC

G02AD03