U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C10H12ClN3O3S
Molecular Weight 289.739
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of QUINETHAZONE

SMILES

CCC1NC(=O)C2=C(N1)C=C(Cl)C(=C2)S(N)(=O)=O

InChI

InChIKey=AGMMTXLNIQSRCG-UHFFFAOYSA-N
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)

HIDE SMILES / InChI

Molecular Formula C10H12ClN3O3S
Molecular Weight 289.739
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/19636250

Quinethazone (brand name Hydromox) is a thiazide diuretic used to treat hypertension. The antihypertensive mechanism of quinethazone is less well understood. This drug was discovered in a period when only isoform carbonic anhydrases (CAs) II was known and considered physiologically/pharmacologically relevant. Recently was studied that quinethazone considerably inhibit other isozymes known nowadays to be involved in critical physiologic processes. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. Common side effects include dizziness, dry mouth, nausea, and low potassium levels. Thiazides may increase the toxicity of allopurinol, anesthetics, antineoplastic, calcium salts, diazoxide, digitalis, lithium; loop diuretics, methyldopa, nondepolarizing muscle relaxants, vitamin D; amphotericin B and anticholinergics may increase the toxicity of thiazides.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
HYDROMOX

Approved Use

Unknown

Launch Date

-2.12371194E11
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

50-100 mg once daily; usual maximum: 200 mg/day
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:11:53 UTC 2023
Edited
by admin
on Fri Dec 15 16:11:53 UTC 2023
Record UNII
455E0S048W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
QUINETHAZONE
HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USP-RS   VANDF   WHO-DD  
INN  
Official Name English
QUINETHAZONE [JAN]
Common Name English
NSC-759904
Code English
6-QUINAZOLINESULFONAMIDE, 7-CHLORO-2-ETHYL-1,2,3,4-TETRAHYDRO-4-OXO-
Systematic Name English
QUINETHAZONE COMPONENT OF HYDROMOX R
Common Name English
HYDROMOX
Brand Name English
QUINETHAZONE [MART.]
Common Name English
QUINETHAZONE [ORANGE BOOK]
Common Name English
7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide
Systematic Name English
QUINETHAZONE [VANDF]
Common Name English
QUINETHAZONE [HSDB]
Common Name English
quinethazone [INN]
Common Name English
HYDROMOX R COMPONENT QUINETHAZONE
Common Name English
Quinethazone [WHO-DD]
Common Name English
QUINETHAZONE [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC C03BA02
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
WHO-VATC QC03BB02
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
WHO-VATC QC03BA02
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
WHO-ATC C03BB02
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
NCI_THESAURUS C49185
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1532
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
DRUG BANK
DB01325
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
NCI_THESAURUS
C66501
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
MESH
C050700
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
HSDB
3392
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
CHEBI
8717
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
IUPHAR
7289
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
INN
998
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
EPA CompTox
DTXSID9023548
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
MERCK INDEX
m9442
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY Merck Index
CAS
73-49-4
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
RXCUI
59743
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY RxNorm
EVMPD
SUB10213MIG
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
PUBCHEM
6307
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
FDA UNII
455E0S048W
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
SMS_ID
100000080277
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
DRUG CENTRAL
2343
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
NSC
759904
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
WIKIPEDIA
QUINETHAZONE
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-801-7
Created by admin on Fri Dec 15 16:11:53 UTC 2023 , Edited by admin on Fri Dec 15 16:11:53 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY