Details
Stereochemistry | RACEMIC |
Molecular Formula | C10H12ClN3O3S |
Molecular Weight | 289.739 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1NC(=O)C2=C(N1)C=C(Cl)C(=C2)S(N)(=O)=O
InChI
InChIKey=AGMMTXLNIQSRCG-UHFFFAOYSA-N
InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
Molecular Formula | C10H12ClN3O3S |
Molecular Weight | 289.739 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18600270Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19636250
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18600270
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/19636250
Quinethazone (brand name Hydromox) is a thiazide diuretic used to treat hypertension. The antihypertensive mechanism of quinethazone is less well understood. This drug was discovered in a period when only isoform carbonic anhydrases (CAs) II was known and considered physiologically/pharmacologically relevant. Recently was studied that quinethazone considerably inhibit other isozymes known nowadays to be involved in critical physiologic processes. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. Common side effects include dizziness, dry mouth, nausea, and low potassium levels. Thiazides may increase the toxicity of allopurinol, anesthetics, antineoplastic, calcium salts, diazoxide, digitalis, lithium; loop diuretics, methyldopa, nondepolarizing muscle relaxants, vitamin D; amphotericin B and anticholinergics may increase the toxicity of thiazides.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2095180 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18600270 |
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Target ID: CHEMBL1876 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20528637 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | HYDROMOX Approved UseUnknown Launch Date1963 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/mmx/quinethazone.html
50-100 mg once daily; usual maximum: 200 mg/day
Route of Administration:
Oral
Substance Class |
Chemical
Created
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admin
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Edited
Fri Dec 15 16:11:53 GMT 2023
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Fri Dec 15 16:11:53 GMT 2023
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Record UNII |
455E0S048W
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Record Status |
Validated (UNII)
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WHO-ATC |
C03BA02
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WHO-VATC |
QC03BB02
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QC03BA02
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WHO-ATC |
C03BB02
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NCI_THESAURUS |
C49185
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CHEMBL1532
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DB01325
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C66501
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C050700
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m9442
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73-49-4
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59743
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SUB10213MIG
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100000080277
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759904
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QUINETHAZONE
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200-801-7
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Related Record | Type | Details | ||
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ACTIVE MOIETY |