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Details

Stereochemistry ACHIRAL
Molecular Formula C16H13N3O3
Molecular Weight 295.2927
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIMETAZEPAM

SMILES

CN1C2=C(C=C(C=C2)[N+]([O-])=O)C(=NCC1=O)C3=CC=CC=C3

InChI

InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N
InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

HIDE SMILES / InChI

Molecular Formula C16H13N3O3
Molecular Weight 295.2927
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Nimetazepam (Erimin) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized in 1962 in Japan. It does possess hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also an anticonvulsant. It is sold in 5 mg tablets known as Erimin. It is generally prescribed for the treatment of short-term severe insomnia in patients who have difficulty falling asleep or maintaining sleep. Nimetazepam is currently a Schedule IV drug under the international Convention on Psychotropic Substances of 1971. In Singapore, nimetazepam is a class C drug under the Misuse of Drugs Act. In Hong Kong, nimetazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Nimetazepam can only be used legally by health professionals and for university research purposes.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
8.52 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Erimin

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
In general, for adults, take 1 tablet (5 mg of the active ingredient) at a time, before bedtime (just before going to sleep).
Route of Administration: Oral
In Vitro Use Guide
By exposure to 100 uM nimetazepam the cell viability in the presence of CYP3A4 decreased more than 25% compared with that of the control.
Substance Class Chemical
Record UNII
4532264KW6
Record Status Validated (UNII)
Record Version