PYRIDAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H4N2
Molecular Weight	80.088
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CC=NN=C1

InChI

InChIKey=PBMFSQRYOILNGV-UHFFFAOYSA-N

InChI=1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H

HIDE SMILES / InChI

Molecular Formula	C4H4N2
Molecular Weight	80.088
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.	2001 Aug 16	11495583
Bis[3,6-bis(6-methyl-2pyridyl)pyridazine-kappa2N2,N3]chlorocopper(II) perchlorate.	2001 Jan	11173394
Binuclear complexes as building blocks for polynuclear complexes with high-spin ground states: synthesis and structure of a tetranuclear nickel complex with an S = 4 ground state.	2001 Oct 1	11686605
A meso-helical coordination polymer from achiral dinuclear [Cu2(H3CCN)2(micro-pydz)3][PF6]2 and 1,3-bis(diphenylphosphanyl)propane-synthesis and crystal structure of 1 to infinity Cu(mu-pydz)2][PF6 (pydz=pyridazine).	2001 Sep 17	11596943
Cross-coupling reactions of phenylmagnesium halides with fluoroazines and fluorodiazines.	2002 Dec 13	12467419
Pyridazine based inhibitors of p38 MAPK.	2002 Feb 25	11844702
A study by ultraviolet spectroscopy on the self-association of diazines in aqueous solution.	2003 Apr	12659891
Synthesis, crystal structures, and thermal and thermodynamic properties of dimorphic copper(I) coordination polymers.	2003 May 5	12716189
Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.	2003 Nov	14570769
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.	2003 Nov 17	14592490
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.	2003 Oct 20	14505650
Quaternary salts containing the pentafluorosulfanyl (SF5) group.	2003 Sep 22	12971788
Synthesis and chemistry of unusual bicyclic endoperoxides containing the pyridazine ring.	2003 Sep 5	12946142
Synthesis of 5-azaindolizine derivatives by the palladium-catalyzed intermolecular formal [3+2] cycloaddition of alkylidenecyclopropanes with 1,2-diazines.	2004 Apr 30	15104465
Synthesis and herbicidal activity of novel heterocyclic protoporphyrinogen oxidase inhibitors.	2004 Dec	15578598
New developments in the symmetry-adapted algorithm of the Polarizable Continuum Model.	2004 Feb	14696072
Structural distortion of pyridazine in the 1(n, pi) excited state: evidence for local excitation.	2004 May 17	15179730
Pyridazine derivatives and related compounds. Part 13: Synthesis and antimicrobial activity of some pyridazino[3',4':3,4]pyrazolo[5,1-c]-1,2,4-triazines.	2004 Oct 4	15341971
Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activity.	2005 Apr	15918510
Neutral Cu4N12 and Ag4N12 metallacycles with a para-cyclophane framework assembled from copper(I) and silver(I) pyrazolates and pyridazine.	2005 Mar 28	15770279
Fully dimensional ab initio description of the structure and energetics of azabenzene-argon complexes.	2005 Oct 15	16252943
Vibrational spectra and potential energy distributions for 4,5-dichloro-3-hydroxypyridazine by density functional theory and normal coordinate calculations.	2005 Sep	16043044
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.	2006 Apr 20	16610803
Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.	2006 Aug	16896543
Synthetic approaches to polypyridyl bridging ligands with proximal multidentate binding sites.	2006 Jan 6	16388632
The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats.	2006 Jan-Mar	16715779
Copper complexes with heterocyclic sulfonamides: synthesis, spectroscopic characterization, microbiological and SOD-like activities: crystal structure of [Cu(sulfisoxazole)2(H2O)4] . 2H2O.	2006 Jul	16584779
Kinetics and mechanism of the reactions of Pd(II) complexes with azoles and diazines. Crystal structure of [Pd(bpma)(H2O)](ClO4)2.2H2O.	2006 Jun 28	16770458
Vibrational spectroscopy of the pyridazine cation in the ground state.	2006 Mar 2	16494373
CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors.	2007 Jul	17140831
Silver(I) sulfate coordination polymers with 4,4'-bipyridazine and pyridazino[4,5-d]pyridazine.	2007 Jun	17551184

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:35:27 GMT 2023` Edited by `admin` on `Sat Dec 16 01:35:27 GMT 2023`
Record UNII	449GLA0653
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRIDAZINE

Systematic Name

English

PYRIDAZINE [MI]

Common Name

English

OIZINE

Common Name

English

1,2-DIAZINE

Systematic Name

English

NSC-90792

Code

English

ORTHODIAZINE

Systematic Name

English

Code System Code Type Description

FDA UNII

449GLA0653