PYRIDAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H4N2
Molecular Weight	80.088
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1=CN=NC=C1

InChI

InChIKey=PBMFSQRYOILNGV-UHFFFAOYSA-N

InChI=1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H

HIDE SMILES / InChI

Molecular Formula	C4H4N2
Molecular Weight	80.088
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors.	2007-07	17140831
Silver(I) sulfate coordination polymers with 4,4'-bipyridazine and pyridazino[4,5-d]pyridazine.	2007-06	17551184
Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.	2007-06	17353349
13C-1H HSQC experiment of probe molecules aligned in thermotropic liquid crystals: sensitivity and resolution enhancement in the indirect dimension.	2007-04	17223368
Luminescent hydrido-carbonyl clusters of rhenium containing bridging 1,2-diazine ligands.	2006-12-25	17173450
A self-assembled hexadecanuclear 4 x[2 x 2] Mn(II)16 square grid from a pyridazine bis(hydrazone) ligand: synthesis, structure and magnetism.	2006-12-21	17136263
Metal-organic frameworks exhibiting strong anion-pi interactions.	2006-12-14	17345736
Estimation of local density augmentation and hydrogen bonding between pyridazine and water under sub- and supercritical conditions using UV-vis spectroscopy.	2006-11	17099272
Donor-acceptor-donor-type liquid crystal with a pyridazine core.	2006-10-12	17020281
A computational study on pi and sigma modes of metal ion binding to heteroaromatics (CH)(5-m)X(m) and (CH)(6-m)X(m) (X = N and P): contrasting preferences between nitrogen- and phosphorous-substituted rings.	2006-08-24	16913690
Triphenylene analogues with B2N2C2 cores: synthesis, structure, redox behavior, and photophysical properties.	2006-08-23	16910684
Use of 4-bromo pyridazine 3,6-dione for building 3-amino pyridazine libraries.	2006-08	16896543
3-Benzidino-6(4-chlorophenyl) pyridazine blocks delayed rectifier and transient outward potassium current in acutely isolated rat hippocampal pyramidal neurons.	2006-07-10	16647816
Pulsed-field ionization electron spectroscopy and ab initio calculations of copper-diazine complexes.	2006-07-07	16863300
Copper complexes with heterocyclic sulfonamides: synthesis, spectroscopic characterization, microbiological and SOD-like activities: crystal structure of [Cu(sulfisoxazole)2(H2O)4] . 2H2O.	2006-07	16584779
A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties.	2006-06-29	16789729
Kinetics and mechanism of the reactions of Pd(II) complexes with azoles and diazines. Crystal structure of [Pd(bpma)(H2O)](ClO4)2.2H2O.	2006-06-28	16770458
The in vivo metabolism of 3-oxo-5-benzylidene-6-methyl-(4H)-2-(benzoylmethyl)pyridazine in rats.	2006-05-24	16715779
Anion-pi interactions as controlling elements in self-assembly reactions of Ag(I) complexes with pi-acidic aromatic rings.	2006-05-03	16637658
Determination of natural abundance 15N-1H and 13C-1H dipolar couplings of molecules in a strongly orienting media using two-dimensional inverse experiments.	2006-05	16534832
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.	2006-04-20	16610803
Vibrational spectroscopy of the pyridazine cation in the ground state.	2006-03-02	16494373
Cadmium nitrate coordination polymers with substituted pyridazino[4,5-d]pyridazines.	2006-02	16456278
Pyrrolopyridazine MEK inhibitors.	2006-02	16275076
Synthetic approaches to polypyridyl bridging ligands with proximal multidentate binding sites.	2006-01-06	16388632
Monoclinic and triclinic concomitant polymorphs of di-mu-pyridazine-1kappa(2)N:2kappa(2)N'-bis[(saccharinato)silver(I)].	2006-01	16397317
Current status of anti-picornavirus therapies.	2006	16611122
Hydrogen bond directed synthesis of pyridazine and naphthyridine containing macrocycles.	2005-12-14	16307134
Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors.	2005-12-01	16302810
Synthesis of new series of 1-Aryl-1,4-dihydro-4-oxo-6-methyl pyridazine-3-carboxylic acid as potential antibacterial agents.	2005-12	16126308
Interplay between intra- and interligand charge transfer with variation of the axial N-heterocyclic ligand in osmium(II) pyridylpyrazolate complexes: extensive color tuning by phosphorescent solvatochromism.	2005-10-21	16086340
Fully dimensional ab initio description of the structure and energetics of azabenzene-argon complexes.	2005-10-15	16252943
Cyclization reactions of acylium and thioacylium ions with isocyanates and isothiocyanates: gas phase synthesis of 3,4-dihydro-2,4-dioxo-2H-1,3,5-oxadiazinium ions.	2005-10	16087345
A new pyridazine series of GABAA alpha5 ligands.	2005-09-22	16162003
Vibrational spectra and potential energy distributions for 4,5-dichloro-3-hydroxypyridazine by density functional theory and normal coordinate calculations.	2005-09	16043044
Dye-sensitized photooxygenation of furanosyl furans: synthesis of a new pyridazine C-nucleoside.	2005-08-05	16050717
Total synthesis of ningalin D.	2005-08-03	16045367
Dimetallic complexes of a structurally versatile pyridazine-containing Schiff-base macrocyclic ligand with pendant pyridine arms.	2005-07-21	15995756
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.	2005-05-02	15837335
Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model.	2005-04	15974919
Synthesis of 3-alkylthio-6-allylthiopyridazine derivatives and their antihepatocarcinoma activity.	2005-04	15918510
Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan acetylcholine binding protein (AChBP).	2005-04	15848206
Neutral Cu4N12 and Ag4N12 metallacycles with a para-cyclophane framework assembled from copper(I) and silver(I) pyrazolates and pyridazine.	2005-03-28	15770279
3,6-bis(2'-pyridyl)pyridazine (L) and its deprotonated form (L - H+)- as ligands for {(acac)2Ru(n+)} or {(bpy)2Ru(m+)}: investigation of mixed valency in [{(acac)2Ru}2(mu-L - H+)]0 and [{(bpy)2Ru}2(mu-L - H+)]4+ by spectroelectrochemistry and EPR.	2005-02-21	15702181
Synthesis and herbicidal activity of novel heterocyclic protoporphyrinogen oxidase inhibitors.	2004-12	15578598
5'-(2-phosphoryl-1,4-dioxobutane) as a product of 5'-oxidation of deoxyribose in DNA: elimination as trans-1,4-dioxo-2-butene and approaches to analysis.	2004-11	15540938
Pyridazine derivatives and related compounds. Part 13: Synthesis and antimicrobial activity of some pyridazino[3',4':3,4]pyrazolo[5,1-c]-1,2,4-triazines.	2004-10-04	15341971
Zonal ablation of the olfactory sensory neuroepithelium of the mouse: effects on odorant detection.	2004-10	15380007
The influence of water on the rates of 1,3-dipolar cycloaddition reactions: trigger points for exponential rate increases in water-organic solvent mixtures. Water-super versus water-normal dipolarophiles.	2004-09-29	15382927
N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy.	2004-09-09	15341487

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:54:34 GMT 2025` Edited by `admin` on `Mon Mar 31 20:54:34 GMT 2025`
Record UNII	449GLA0653
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PYRIDAZINE

Systematic Name

English

NSC-90792

Preferred Name

English

PYRIDAZINE [MI]

Common Name

English

OIZINE

Common Name

English

1,2-DIAZINE

Systematic Name

English

ORTHODIAZINE

Systematic Name

English

Code System Code Type Description

FDA UNII

449GLA0653