U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C18H18N2O
Molecular Weight 278.3483
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROQUAZONE

SMILES

CC(C)N1C(=O)N=C(C2=CC=CC=C2)C3=C1C=C(C)C=C3

InChI

InChIKey=JTIGKVIOEQASGT-UHFFFAOYSA-N
InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

HIDE SMILES / InChI

Molecular Formula C18H18N2O
Molecular Weight 278.3483
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Proquazon, a non-steroidal anti-inflammatory agent that was studied to use in the management of rheumatoid arthritis and osteoarthritis. The biochemical mechanism of action of proquazon via the inhibition of the core protein synthesis of proteoglycans and the secondary biosynthesis of the glucosamine.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

PubMed

Sample Use Guides

In Vivo Use Guide
proquazone 300 to 900 mg/day
Route of Administration: Oral
Substance Class Chemical
Record UNII
42VPJ2980S
Record Status Validated (UNII)
Record Version