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Details

Stereochemistry ACHIRAL
Molecular Formula C18H18N2O
Molecular Weight 278.3483
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROQUAZONE

SMILES

CC(C)N1C(=O)N=C(C2=CC=CC=C2)C3=CC=C(C)C=C13

InChI

InChIKey=JTIGKVIOEQASGT-UHFFFAOYSA-N
InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

HIDE SMILES / InChI

Molecular Formula C18H18N2O
Molecular Weight 278.3483
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Proquazon, a non-steroidal anti-inflammatory agent that was studied to use in the management of rheumatoid arthritis and osteoarthritis. The biochemical mechanism of action of proquazon via the inhibition of the core protein synthesis of proteoglycans and the secondary biosynthesis of the glucosamine.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
2003 Jul
Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations.
2003 Summer
Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.
2004 Dec 9
High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine.
2007 Jul-Aug
A peripatetic pediatrician's journey into pediatric rheumatology: Part II.
2007 Jun 21
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Sample Use Guides

proquazone 300 to 900 mg/day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:37:04 GMT 2023
Edited
by admin
on Fri Dec 15 16:37:04 GMT 2023
Record UNII
42VPJ2980S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROQUAZONE
INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
PROQUAZONE [MI]
Common Name English
43-715
Code English
Proquazone [WHO-DD]
Common Name English
PROQUAZONE [MART.]
Common Name English
1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
Systematic Name English
proquazone [INN]
Common Name English
PROQUAZONE [USAN]
Common Name English
PROQUAZONE [JAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
WHO-ATC M01AX13
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
WHO-VATC QM01AX13
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
Code System Code Type Description
WIKIPEDIA
PROQUAZONE
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
CAS
22760-18-5
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
INN
3176
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
EVMPD
SUB10127MIG
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
DRUG CENTRAL
2311
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
MESH
C011385
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
SMS_ID
100000080810
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
NCI_THESAURUS
C73093
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
PUBCHEM
31508
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID4021210
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
ECHA (EC/EINECS)
245-203-7
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
MERCK INDEX
m9254
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY Merck Index
FDA UNII
42VPJ2980S
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
ChEMBL
CHEMBL268501
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
DRUG BANK
DB13649
Created by admin on Fri Dec 15 16:37:04 GMT 2023 , Edited by admin on Fri Dec 15 16:37:04 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY