PROQUAZONE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)N1C(=O)N=C(C2=CC=CC=C2)C3=C1C=C(C)C=C3

InChI

InChIKey=JTIGKVIOEQASGT-UHFFFAOYSA-N

InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3

HIDE SMILES / InChI

Molecular Formula	C18H18N2O
Molecular Weight	278.3483
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3297621 |https://www.ncbi.nlm.nih.gov/pubmed/442844

Proquazon, a non-steroidal anti-inflammatory agent that was studied to use in the management of rheumatoid arthritis and osteoarthritis. The biochemical mechanism of action of proquazon via the inhibition of the core protein synthesis of proteoglycans and the secondary biosynthesis of the glucosamine.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
proteoglycan biosynthetic process 3 Target ID: GO:0030166 Sources: https://www.ncbi.nlm.nih.gov/pubmed/442844	Inhibitor 8504

PubMed

Title	Date	PubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010-12	21818443
High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine.	2007-09-01	17760334
A peripatetic pediatrician's journey into pediatric rheumatology: Part II.	2007-06-21	17584931
Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.	2004-12-09	15541920
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.	2003-07	12770513
Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations.	2003	12835494

Patents

Sample Use Guides

In Vivo Use Guide

proquazone 300 to 900 mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:44 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:44 GMT 2025`
Record UNII	42VPJ2980S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

43-715

Preferred Name

English

PROQUAZONE

Official Name

English

PROQUAZONE [MI]

Common Name

English

Proquazone [WHO-DD]

Common Name

English

PROQUAZONE [MART.]

Common Name

English

1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone

Systematic Name

English

proquazone [INN]

Common Name

English

PROQUAZONE [USAN]

Common Name

English

PROQUAZONE [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257