Details
Stereochemistry | ACHIRAL |
Molecular Formula | C28H37NO2 |
Molecular Weight | 419.5989 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 6 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(=O)OCC1=CC=CN=C1
InChI
InChIKey=BUWVEXMRBAWBPJ-KUBAVDMBSA-N
InChI=1S/C28H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23-28(30)31-26-27-22-21-24-29-25-27/h3-4,6-7,9-10,12-13,15-16,18-19,21-22,24-25H,2,5,8,11,14,17,20,23,26H2,1H3/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-
Molecular Formula | C28H37NO2 |
Molecular Weight | 419.5989 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 6 |
Optical Activity | NONE |
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:44:24 UTC 2023
by
admin
on
Sat Dec 16 11:44:24 UTC 2023
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Record UNII |
42L7PA2MAV
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Record Status |
Validated (UNII)
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Record Version |
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-
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42L7PA2MAV
Created by
admin on Sat Dec 16 11:44:24 UTC 2023 , Edited by admin on Sat Dec 16 11:44:24 UTC 2023
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92510-91-3
Created by
admin on Sat Dec 16 11:44:24 UTC 2023 , Edited by admin on Sat Dec 16 11:44:24 UTC 2023
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14671646
Created by
admin on Sat Dec 16 11:44:24 UTC 2023 , Edited by admin on Sat Dec 16 11:44:24 UTC 2023
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ACTIVE MOIETY |
The aim of the present study was to investigate the effects of a new pure docosahexaenoic acid derivative called F 16915 in experimental models of heart failure-induced atria dysfunction. The atrial dysfunction-induced AF was investigated (1) in a dog model of tachypacing-induced congestive heart failure and (2) in a rat model of heart failure induced by occlusion of left descending coronary artery and 2 months reperfusion. F 16915 (5 g/day for 4 weeks) significantly reduced the mean duration of AF induced by burst pacing in the dog model (989 +/- 111 s in the vehicle group to 79 +/- 59 s with F 16915, P < 0.01). This dose of F 16915 also significantly reduced the incidence of sustained AF (5/5 dogs in the vehicle group versus 1/5 with F 16915, P < 0.05). In the rat model, the percentage of shortening fraction in the F 16915 group (100 mg/kg p.o. daily) was significantly restored after 2 months (32.6 +/- 7.4 %, n = 9 vs 17.6 +/- 3.4 %, n = 9 in the vehicle group, P < 0.01). F 16915 also reduced the de-phosphorylation of connexin43 from atria tissue. The present results show that treatment with F 16915 reduced the heart dilation, resynchronized the gap junction activity, and reduced the AF duration in models of heart failure.
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