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Details

Stereochemistry ABSOLUTE
Molecular Formula C32H38N2O8
Molecular Weight 578.6527
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEFESERPINE

SMILES

CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=CC(OC)=CC=C45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)COC6=CC=C(OC)C=C6

InChI

InChIKey=KFDDPVMIQMFHBI-JLIPXIIDSA-N
InChI=1S/C32H38N2O8/c1-37-19-5-7-20(8-6-19)41-17-28(35)42-27-13-18-16-34-12-11-23-22-10-9-21(38-2)14-25(22)33-30(23)26(34)15-24(18)29(31(27)39-3)32(36)40-4/h5-10,14,18,24,26-27,29,31,33H,11-13,15-17H2,1-4H3/t18-,24+,26-,27-,29+,31+/m1/s1

HIDE SMILES / InChI

Molecular Formula C32H38N2O8
Molecular Weight 578.6527
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Mefeserpine (Methoxyphenoserpine) is a hypotensive reserpoid with a weak central depressive effect.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Rats: The dose of 25.0 mg/kg causing the comparable increase of the concentration of pepsin in the gastric juice of normal rats is 5 times higher than that of reserpine.
Route of Administration: Intraperitoneal
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
42EL4L295A
Record Status Validated (UNII)
Record Version