MEFESERPINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C32H38N2O8
Molecular Weight	578.6527
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=CC(OC)=CC=C45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)COC6=CC=C(OC)C=C6

InChI

InChIKey=KFDDPVMIQMFHBI-JLIPXIIDSA-N

InChI=1S/C32H38N2O8/c1-37-19-5-7-20(8-6-19)41-17-28(35)42-27-13-18-16-34-12-11-23-22-10-9-21(38-2)14-25(22)33-30(23)26(34)15-24(18)29(31(27)39-3)32(36)40-4/h5-10,14,18,24,26-27,29,31,33H,11-13,15-17H2,1-4H3/t18-,24+,26-,27-,29+,31+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C32H38N2O8
Molecular Weight	578.6527
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14336535 | https://www.ncbi.nlm.nih.gov/pubmed/14332286

Mefeserpine (Methoxyphenoserpine) is a hypotensive reserpoid with a weak central depressive effect.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14269470 https://www.ncbi.nlm.nih.gov/pubmed/14332286	Primary		Approved 8583	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[THE USE OF METHOXYPHENOSERPINE, A RESERPINE DERIVATIVE, IN THE TREATMENT OF HYPERTENSIVE DISEASE].	1965-03	14332286
[CLINICAL EVALUATION OF METHOXYPHENOSERPINE, A SYNTHETIC DERIVATIVE OF RESERPINE].	1965	14269470
THE INFLUENCE OF A NEW RESERPINE DERIVATIVE, METHOXYPHENOSERPINE, ON EXPERIMENTAL ULCERS AND GASTRIC SECRETION IN RATS.	1964-05	14336535
[HYPOTENSIVE AND SIDE-EFFECTS OF METHOXYPHENOSERPINE, A NEW RESERPINE DERIVATIVE].	1963-11-15	14111753

Patents

Sample Use Guides

In Vivo Use Guide

Rats: The dose of 25.0 mg/kg causing the comparable increase of the concentration of pepsin in the gastric juice of normal rats is 5 times higher than that of reserpine.

Route of Administration: Intraperitoneal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:36:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:36:18 GMT 2025`
Record UNII	42EL4L295A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEFESERPINE

Official Name

English

METHYL RESERPATE ESTER OF (P-METHOXYPHENOXY)ACETIC ACID

Preferred Name

English

mefeserpine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270