QUINESTRADOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H32O3
Molecular Weight	356.4984
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](O)[C@H](O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(OC5CCCC5)C=C4

InChI

InChIKey=ODYKCPYPRCJXLY-PZORDLPLSA-N

InChI=1S/C23H32O3/c1-23-11-10-18-17-9-7-16(26-15-4-2-3-5-15)12-14(17)6-8-19(18)20(23)13-21(24)22(23)25/h7,9,12,15,18-22,24-25H,2-6,8,10-11,13H2,1H3/t18-,19-,20+,21-,22+,23+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H32O3
Molecular Weight	356.4984
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1220592 | https://www.ncbi.nlm.nih.gov/pubmed/4960138 | https://www.ncbi.nlm.nih.gov/pubmed/4890404

Quinestradol is an estrogen derivative patented by Francesco Vismara Societa per Azioni and Alberto Ercol for the treatment of senile vulvovaginitis and related conditions. In preclinical trilals, quinestradol shows feminizing action in rats. A clinical trial of Quinestradol appeared to be justified since there was considerable evidence that the preparation was safe and free from side effects.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Effects of estriol and quinestradol administered to pregnant rats on the fetal sex differentiation].	1975 Mar-Apr	1220592
Temporal relationships between hormone receptor binding and biological responses in the uterus: studies with short- and long-acting derivatives of estriol.	1976 Jan	174891
Biology and receptor interactions of estriol and estriol derivatives in vitro and in vivo.	1984 Apr	6727348

Patents

Sample Use Guides

In Vivo Use Guide

0.25 mg four times a day.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:32 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:32 GMT 2023`
Record UNII	422L8173W8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUINESTRADOL

Official Name

English

quinestradol [INN]

Common Name

English

QUINESTRADOL [MART.]

Common Name

English

QUINESTRADIOL [MI]

Common Name

English

Quinestradol [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C483