QUINESTRADOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H32O3
Molecular Weight	356.4984
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@]12CC[C@H]3[C@@H](CCC4=CC(OC5CCCC5)=CC=C34)[C@@H]1C[C@@H](O)[C@@H]2O

InChI

InChIKey=ODYKCPYPRCJXLY-PZORDLPLSA-N

InChI=1S/C23H32O3/c1-23-11-10-18-17-9-7-16(26-15-4-2-3-5-15)12-14(17)6-8-19(18)20(23)13-21(24)22(23)25/h7,9,12,15,18-22,24-25H,2-6,8,10-11,13H2,1H3/t18-,19-,20+,21-,22+,23+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C23H32O3
Molecular Weight	356.4984
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1220592 | https://www.ncbi.nlm.nih.gov/pubmed/4960138 | https://www.ncbi.nlm.nih.gov/pubmed/4890404

Quinestradol is an estrogen derivative patented by Francesco Vismara Societa per Azioni and Alberto Ercol for the treatment of senile vulvovaginitis and related conditions. In preclinical trilals, quinestradol shows feminizing action in rats. A clinical trial of Quinestradol appeared to be justified since there was considerable evidence that the preparation was safe and free from side effects.

Originator

Approval Year

PubMed

Title	Date	PubMed
Biology and receptor interactions of estriol and estriol derivatives in vitro and in vivo.	1984-04	6727348
Temporal relationships between hormone receptor binding and biological responses in the uterus: studies with short- and long-acting derivatives of estriol.	1976-01	174891
[Effects of estriol and quinestradol administered to pregnant rats on the fetal sex differentiation].	1975-03-01	1220592

Patents

Sample Use Guides

In Vivo Use Guide

0.25 mg four times a day.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:57 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:57 GMT 2025`
Record UNII	422L8173W8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUINESTRADOL

Official Name

English

QUINESTRADIOL [MI]

Preferred Name

English

quinestradol [INN]

Common Name

English

QUINESTRADOL [MART.]

Common Name

English

Quinestradol [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C483