POTASSIUM PERCHLORATE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	ClO4.K
Molecular Weight	138.549
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].[O-]Cl(=O)(=O)=O

InChI

InChIKey=YLMGFJXSLBMXHK-UHFFFAOYSA-M

InChI=1S/ClHO4.K/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	ClO4
Molecular Weight	99.451
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://ehs.msu.edu/lab-clinic/chem/perchloric.html | https://www.ncbi.nlm.nih.gov/pubmed/18960325

Perchloric acid is a strong acid used for complete digestions of organic material. To prevent injury, goggles or face shield, gloves, and apron must be worn. Perchloric acid must not be mixed with any other waste and should be stored separately from the other chemicals.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperthyroidism 13 Sources: http://www.nuclearonline.org/PI/Mallicknrodt%20perchorate%20Cap.pdf	Primary		Approved 8429	PERCHLORACAP Approved Use Unknown

PubMed

Title	Date	PubMed
Application of perchloric acid technique to protozoa.	1949 Dec 16	15396019
Perchloric acid in the cytochemistry of pentose nucleic acid.	1949 Nov 4	15392949
Loss of ATP in micromolar amounts after perchloric acid treatment.	1976 Nov 5	186755
Purification and characterization of (per)chlorate reductase from the chlorate-respiring strain GR-1.	1999 Nov	10542172
Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution.	2002 Feb	11834455
The pharmacokinetics of perchlorate and its effect on the hypothalamus-pituitary-thyroid axis in the male rat.	2002 Jul 15	12140178
Functional activity of human sodium/iodide symporter in tumor cell lines.	2003 Feb	12601449
Probasin promoter (ARR(2)PB)-driven, prostate-specific expression of the human sodium iodide symporter (h-NIS) for targeted radioiodine therapy of prostate cancer.	2003 Nov 15	14633711
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains.	2004 Apr 13	15065880
Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy.	2004 Sep	15347726
A novel therapeutic strategy for medullary thyroid cancer based on radioiodine therapy following tissue-specific sodium iodide symporter gene expression.	2005 Aug	15941870
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.	2005 Feb 1	15664814
The BeWo choriocarcinoma cell line as a model of iodide transport by placenta.	2005 May	15850642
Development of a rat dosimetry model for bromate.	2006 Apr 17	16500013
Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors.	2006 Jan 5	16289343
Effects of prolonged exposure to perchlorate on thyroid and reproductive function in zebrafish.	2007 Apr	17205975
Cell-based imaging of sodium iodide symporter activity with the yellow fluorescent protein variant YFP-H148Q/I152L.	2007 Feb	16987991
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.	2007 Mar	17332529
Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1. Effects on the brain.	2007 May 31	17403546
Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 2. Effects on the tail and hindlimb.	2007 May 31	17399805
Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis.	2009 Jan 27	18801409
Thyroid hormone may regulate mRNA abundance in liver by acting on microRNAs.	2010 Aug 13	20808432
Perchlorate transport and inhibition of the sodium iodide symporter measured with the yellow fluorescent protein variant YFP-H148Q/I152L.	2010 Mar 15	20005887
Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate.	2010 Nov	20530234
Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants.	2010 Sep	20439182
The effects of perchlorate on thyroidal gene expression are different from the effects of iodide deficiency.	2011	21623536
Biomarker expression in lung of rabbit with pulmonary fibrosis induced by ammonium perchlorate.	2011 Apr	20937628
Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid.	2018 Aug	29709451

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:35:27 GMT 2023` Edited by `admin` on `Fri Dec 15 16:35:27 GMT 2023`
Record UNII	42255P5X4D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

POTASSIUM PERCHLORATE

Systematic Name

English

POTASSIUM PERCHLORATE [HSDB]

Common Name

English

PERCHLORACAP

Brand Name

English

POTASSIUM PERCHLORATE [ORANGE BOOK]

Common Name

English

POTASSIUM PERCHLORATE [VANDF]

Common Name

English

POTASSIUM PERCHLORATE [EP MONOGRAPH]

Common Name

English

Potassium perchlorate [WHO-DD]

Common Name

English

POTASSIUM PERCHLORATE [MI]

Common Name

English

POTASSIUM PERCHLORATE [USP MONOGRAPH]

Common Name

English

POTASSIUM PERCHLORATE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

H03BC01