BEFUNOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H21NO4
Molecular Weight	291.3422
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)COC1=CC=CC2=C1OC(=C2)C(C)=O

InChI

InChIKey=ZPQPDBIHYCBNIG-UHFFFAOYSA-N

InChI=1S/C16H21NO4/c1-10(2)17-8-13(19)9-20-14-6-4-5-12-7-15(11(3)18)21-16(12)14/h4-7,10,13,17,19H,8-9H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C16H21NO4
Molecular Weight	291.3422
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/14977495

Befunolol is a beta-adrenergic receptor blocker approved in Japan for the treatment of open-angle glaucoma. The current drug status is unknown.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11163052	Antagonist 2778		8.97 null [pKd]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Open-angle glaucoma 51 Sources: http://www.ncbi.nlm.nih.gov/pubmed/11163052	Primary		Approved 8429	BENTOS Approved Use Unknown

PubMed

Title	Date	PubMed
Aqueous humor dynamics in beagle dogs with caffeine-induced ocular hypertension.	1998 Jun	9673947
Contact dermatitis to topical drugs for glaucoma.	2001 Dec	11753897
Human corneal equivalent as cell culture model for in vitro drug permeation studies.	2004 Apr	15031177
Human cornea construct HCC-an alternative for in vitro permeation studies? A comparison with human donor corneas.	2005 Jul	15939241
Utilization of 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) for kinetic spectrophotometric assay of befunolol hydrochloride in its pharmaceutical formulation.	2006 May-Jun	16792064
Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol.	2007 Jan	17177718
Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method.	2009 Jan 30	19087880
Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types.	2010 Oct 29	21139684

Patents

Sample Use Guides

In Vivo Use Guide

1% solution 2 times daily.

Route of Administration: Other

In Vitro Use Guide

Human cornea construct was used to test befunolol (0,5%) permeability.The permeation coefficient was 9,88*10(-6) cm/s.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:03:22 UTC 2023` Edited by `admin` on `Fri Dec 15 16:03:22 UTC 2023`
Record UNII	418546MT3A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BEFUNOLOL

Official Name

English

befunolol [INN]

Common Name

English

Befunolol [WHO-DD]

Common Name

English

7-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2-BENZOFURANYL METHYL KETONE

Systematic Name

English

BEFUNOLOL [MI]

Common Name

English

2-ACETYL-7-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)BENZOFURAN

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

S01ED06