DITOPHAL

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14O2S2
Molecular Weight	254.368
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DITOPHAL

Structure Search

SMILES

CCSC(=O)C1=CC(=CC=C1)C(=O)SCC

InChI

InChIKey=DWGXUDUOJPYAOR-UHFFFAOYSA-N

InChI=1S/C12H14O2S2/c1-3-15-11(13)9-6-5-7-10(8-9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C12H14O2S2
Molecular Weight	254.368
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14497999

Ditophal was used for the treatment of leprosy.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Action of two ethyl thiol esters against experimental tuberculosis in the guinea-pig.	1960 Mar	13814392
Ditophal in the treatment of leprosy.	1962 Jan	14497999
DISTRIBUTION, METABOLISM AND EXCRETION OF PERCUTANEOUSLY ADMINISTERED DITOPHAL ("ETISUL").	1965 Feb	14332458
Chemotherapeutic trials in leprosy. 2. Comparative trial of dapsone plus ditophal (Etisul) and dapsone alone in the treatment of lepromatous leprosy.	1965 Jul-Sep	5322767

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:03:44 GMT 2023` Edited by `admin` on `Fri Dec 15 16:03:44 GMT 2023`
Record UNII	40SR2754GL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DITOPHAL

Official Name

English

ditophal [INN]

Common Name

English

S,S-DIETHYL 1,3-DITHIOISOPHTHALATE

Common Name

English

S,S-DIETHYL ESTER OF 1,3-DITHIOISOPHTHALIC ACID

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C258

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

Code System Code Type Description

PUBCHEM

3083635

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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WIKIPEDIA

DITOPHAL

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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EPA CompTox

DTXSID40207112

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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INN

894

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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EVMPD

SUB06336MIG

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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CAS

584-69-0

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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NCI_THESAURUS

C65445

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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ChEMBL

CHEMBL2104300

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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SMS_ID

100000081860

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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FDA UNII

40SR2754GL

Created by admin on Fri Dec 15 16:03:44 GMT 2023 , Edited by admin on Fri Dec 15 16:03:44 GMT 2023

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Related Record Type Details


					40SR2754GL

DITOPHAL

ACTIVE MOIETY