PF-04531083

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16ClN5O2
Molecular Weight	357.794
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(Cl)C(=C1)C2=C(N)N=C(NC(=O)C3=CC=NN3C)C=C2

InChI

InChIKey=ZRJGMDIPCQOGNI-UHFFFAOYSA-N

InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24)

HIDE SMILES / InChI

Molecular Formula	C17H16ClN5O2
Molecular Weight	357.794
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800031033 | https://www.ncbi.nlm.nih.gov/pubmed/25060923 | https://clinicaltrials.gov/ct2/show/NCT01512160 | https://clinicaltrials.gov/ct2/show/NCT01127906 | https://clinicaltrials.gov/ct2/show/NCT01119235

PF-04531083 is selective Nav1.8 blocker. It has been investigated for the treatment of chronic pain, heart pain, post-surgical dental pain. However, these trials were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Recent progress in sodium channel modulators for pain.	2014-08-15	25060923

Sample Use Guides

In Vivo Use Guide

Single dose - 1000 mg or 2000 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:00:19 GMT 2025` Edited by `admin` on `Mon Mar 31 21:00:19 GMT 2025`
Record UNII	40497CY7Y3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PF-4531083

Preferred Name

English

PF-04531083

Common Name

English

1H-PYRAZOLE-5-CARBOXAMIDE, N-(6-AMINO-5-(2-CHLORO-5-METHOXYPHENYL)-2-PYRIDINYL)-1-METHYL-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB12468