PF-04531083

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H16ClN5O2
Molecular Weight	357.794
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(Cl)C(=C1)C2=C(N)N=C(NC(=O)C3=CC=NN3C)C=C2

InChI

InChIKey=ZRJGMDIPCQOGNI-UHFFFAOYSA-N

InChI=1S/C17H16ClN5O2/c1-23-14(7-8-20-23)17(24)22-15-6-4-11(16(19)21-15)12-9-10(25-2)3-5-13(12)18/h3-9H,1-2H3,(H3,19,21,22,24)

HIDE SMILES / InChI

Molecular Formula	C17H16ClN5O2
Molecular Weight	357.794
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800031033 | https://www.ncbi.nlm.nih.gov/pubmed/25060923 | https://clinicaltrials.gov/ct2/show/NCT01512160 | https://clinicaltrials.gov/ct2/show/NCT01127906 | https://clinicaltrials.gov/ct2/show/NCT01119235

PF-04531083 is selective Nav1.8 blocker. It has been investigated for the treatment of chronic pain, heart pain, post-surgical dental pain. However, these trials were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Recent progress in sodium channel modulators for pain.	2014 Aug 15	25060923

Sample Use Guides

In Vivo Use Guide

Single dose - 1000 mg or 2000 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:46:59 GMT 2023` Edited by `admin` on `Sat Dec 16 01:46:59 GMT 2023`
Record UNII	40497CY7Y3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PF-04531083

Common Name

English

PF-4531083

Code

English

1H-PYRAZOLE-5-CARBOXAMIDE, N-(6-AMINO-5-(2-CHLORO-5-METHOXYPHENYL)-2-PYRIDINYL)-1-METHYL-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB12468