SUCLOFENIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H13ClN2O4S
Molecular Weight	364.803
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC(Cl)=C(C=C1)N2C(=O)CC(C2=O)C3=CC=CC=C3

InChI

InChIKey=JUIHCCIFJCSFON-UHFFFAOYSA-N

InChI=1S/C16H13ClN2O4S/c17-13-8-11(24(18,22)23)6-7-14(13)19-15(20)9-12(16(19)21)10-4-2-1-3-5-10/h1-8,12H,9H2,(H2,18,22,23)

HIDE SMILES / InChI

Molecular Formula	C16H13ClN2O4S
Molecular Weight	364.803
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/583228 | Arzneimittel-Forschung (1977), 27, (10), 1942-53.

Suclofenide is a benzenesulfonamide derivative patented by Geistlich, Ed., Soehne A.-G. fuer Chemische Industrie as anticonvulsant and antiepileptic agent. In preclinical models Suclofenide shows potent anticonvulsant activity against electroshock- and pentylenetetrazole-induced convulsions in mice. Sublethal toxic manifestations were drowsiness, myoclonic twitches, and diarrhea.

Originator

Approval Year

PubMed

Title	Date	PubMed
3-Chloro-4-(phenylsuccinimido)-benzenesulfonamide (GS 385), a new anticonvulsant: its quantitative determination, pharmacokinetics and metabolism using high performance liquid chromatography.	1979	583228

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:02:27 GMT 2023` Edited by `admin` on `Fri Dec 15 18:02:27 GMT 2023`
Record UNII	3V0537Z59Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SUCLOFENIDE

Official Name

English

suclofenide [INN]

Common Name

English

SUCLOFENIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C264