Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:50:05 GMT 2023
by
admin
on
Sat Dec 16 11:50:05 GMT 2023
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Protein Sub Type | |
Sequence Type | COMPLETE |
Record UNII |
3UW2OFC4M0
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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Q9H228
Created by
admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
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PRIMARY | |||
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3UW2OFC4M0
Created by
admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
|
PRIMARY | |||
|
Q9H228
Created by
admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
|
PRIMARY |
Glycosylation Type | HUMAN |
Glycosylation Link Type | Site |
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N | 1_20 |
Related Record | Type | Details | ||
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PARTIAL AGONIST->TARGET |
Relative efficacY of 63% of S1P1 activity 73%
EC50
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
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AGONIST -> TARGET | |||
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
Blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. Initial receptor activation is paradoxically followed by S1P1 functional antagonism, whereby receptors are internalized and degraded, thus reducing or eliminating them from the lymphocyte cell surface.40,60,70,74,75 This down-regulation renders lymphocytes unresponsive to the normal S1P gradient and thus deprives them of the obligatory signal that would ordinarily allow them to egress from lymphoid tissues and recirculate to the periphery.
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
SELECTIVE
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Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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MOL_WEIGHT | CHEMICAL |
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