Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Tue Apr 01 17:07:18 GMT 2025
by
admin
on
Tue Apr 01 17:07:18 GMT 2025
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
3UW2OFC4M0
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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Q9H228
Created by
admin on Tue Apr 01 17:07:18 GMT 2025 , Edited by admin on Tue Apr 01 17:07:18 GMT 2025
|
PRIMARY | |||
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3UW2OFC4M0
Created by
admin on Tue Apr 01 17:07:18 GMT 2025 , Edited by admin on Tue Apr 01 17:07:18 GMT 2025
|
PRIMARY | |||
|
Q9H228
Created by
admin on Tue Apr 01 17:07:18 GMT 2025 , Edited by admin on Tue Apr 01 17:07:18 GMT 2025
|
PRIMARY |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_20 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARTIAL AGONIST->TARGET |
Relative efficacY of 63% of S1P1 activity 73%
EC50
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
Chinese Hamster Ovary (CHO) cells, overexpressing human S1P5 receptor (35S)-GTP-S incorporation assays.
EC50
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
Blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. Initial receptor activation is paradoxically followed by S1P1 functional antagonism, whereby receptors are internalized and degraded, thus reducing or eliminating them from the lymphocyte cell surface.40,60,70,74,75 This down-regulation renders lymphocytes unresponsive to the normal S1P gradient and thus deprives them of the obligatory signal that would ordinarily allow them to egress from lymphoid tissues and recirculate to the periphery.
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
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AGONIST -> TARGET |
SELECTIVE
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AGONIST -> TARGET |
EC50
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|
AGONIST -> TARGET |
SELECTIVE
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO ACID SUBSTITUTION | [1_381] | DEXFOSFOSERINE | VI4F0K069V |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|