U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 11:50:05 GMT 2023
Edited
by admin
on Sat Dec 16 11:50:05 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
3UW2OFC4M0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPHINGOSINE 1-PHOSPHATE RECEPTOR 5
Common Name English
EDG8
Common Name English
SPHINGOSINE 1-PHOSPHATE RECEPTOR EDG-8
Common Name English
ENDOTHELIAL DIFFERENTIATION G-PROTEIN-COUPLED RECEPTOR 8
Common Name English
S1P RECEPTOR EDG-8
Common Name English
S1P RECEPTOR 5
Common Name English
Code System Code Type Description
PHAROS
Q9H228
Created by admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
PRIMARY
FDA UNII
3UW2OFC4M0
Created by admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
PRIMARY
UNIPROT
Q9H228
Created by admin on Sat Dec 16 11:50:05 GMT 2023 , Edited by admin on Sat Dec 16 11:50:05 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_20
Related Record Type Details
PARTIAL AGONIST->TARGET
Relative efficacY of 63% of S1P1 activity 73%
EC50
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
AGONIST -> TARGET
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
Blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. Initial receptor activation is paradoxically followed by S1P1 functional antagonism, whereby receptors are internalized and degraded, thus reducing or eliminating them from the lymphocyte cell surface.40,60,70,74,75 This down-regulation renders lymphocytes unresponsive to the normal S1P gradient and thus deprives them of the obligatory signal that would ordinarily allow them to egress from lymphoid tissues and recirculate to the periphery.
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
AGONIST -> TARGET
SELECTIVE
AGONIST -> TARGET
SELECTIVE
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL