ISARALGAGENE CIVAPARVOVEC

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:00:23 UTC 2023` Edited by `admin` on `Sat Dec 16 19:00:23 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT VIRUS
Source Materials State	LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family	Parvoviridae
Organism Genus	Dependovirus
Organism Species	adeno-associated virus
Infraspecific Type	SUBSTRAIN
Infraspecific Name	Recombinant AAV2/6 Vector ApoE/hAAT/Encoding the cDNA for hGLA (ST-920)
Part	WHOLE
Record UNII	3U2455CVM6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISARALGAGENE CIVAPARVOVEC

Official Name

English

isaralgagene civaparvovec [INN]

Common Name

English

A RECOMBINANT, NON-REPLICATING ADENO-ASSOCIATED VIRAL VECTOR SEROTYPE 6 (AAV6) ENCODING CODON-OPTIMISED HUMAN ALPHA-GALACTOSIDASE A (GLA) UNDER CONTROL OF LIVER-SPECIFIC REGULATORY ELEMENTS (COMPRISING ENHANCER AND HEPATIC CONTROL REGION FROM THE HUMAN A

Common Name

English

ST-920

Code

English

DNA (RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR ST-920 LIVER-SPECIFIC ENHANCER-PROMOTER-INTRON REGULATORY MODULE PLUS HUMAN .ALPHA.-GALACTOSIDASE PRECURSOR-SPECIFYING)

Common Name

English

ST920

Code

English

Code System Code Type Description

NCI_THESAURUS

C179094

Created by admin on Sat Dec 16 19:00:23 UTC 2023 , Edited by admin on Sat Dec 16 19:00:23 UTC 2023

PRIMARY

FDA UNII

3U2455CVM6

Created by admin on Sat Dec 16 19:00:23 UTC 2023 , Edited by admin on Sat Dec 16 19:00:23 UTC 2023

PRIMARY

CAS

2378601-29-5

Created by admin on Sat Dec 16 19:00:23 UTC 2023 , Edited by admin on Sat Dec 16 19:00:23 UTC 2023

PRIMARY

INN

11536

Created by admin on Sat Dec 16 19:00:23 UTC 2023 , Edited by admin on Sat Dec 16 19:00:23 UTC 2023

PRIMARY

INN

Related Record Type Details


					RZD65TSM9U

AGALSIDASE BETA

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					3U2455CVM6

ISARALGAGENE CIVAPARVOVEC

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					UNSPECIFIED SUBSTANCE	fb56e2b3 (not in database)