Lefelsiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 19:01:32 GMT 2023` Edited by `admin` on `Sat Dec 16 19:01:32 GMT 2023`
Nucleic Acid Type	dsRNA
Nucleic Acid Subtype
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	3RJ6WVX57J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Lefelsiran

Official Name

English

all-P-ambo-(3'→5')-2'-O-methyl-P-thioguanylyl-(3'→5')-2'-O-methyl-P-thioguanylyl-(3'→5')-2'-O-methyl-P-thiocytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methyladenylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5'

Common Name

English

DCR-1203 FREE ACID

Code

English

DCR-A1203 FREE ACID

Code

English

LEFELSIRAN [USAN]

Common Name

English

RNA, ([4′-de(hydroxymethyl)-4′-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2′-deoxy-2′-fluoro)A-sp-(2′-deoxy-2′-fluoro)A-sp-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-Um-(2′-deoxy-2′-fluoro)G-Am-Gm-Um-Um-Um-Cm-(2′-deoxy-2′-flu

Common Name

English

Code System Code Type Description

INN

12851

Created by admin on Sat Dec 16 19:01:32 GMT 2023 , Edited by admin on Sat Dec 16 19:01:32 GMT 2023

PRIMARY

USAN

KL-223

Created by admin on Sat Dec 16 19:01:32 GMT 2023 , Edited by admin on Sat Dec 16 19:01:32 GMT 2023

PRIMARY

FDA UNII

3RJ6WVX57J

Created by admin on Sat Dec 16 19:01:32 GMT 2023 , Edited by admin on Sat Dec 16 19:01:32 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_7;1_12-1_36;2_1;2_6;2_8-2_13;2_15-2_22	48 / 58
2'-Fluoro-Ribose	1_8-1_11;2_2-2_5;2_7;2_14	10 / 58

Linkage	Site Range	Site Count
Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56
Phosphate	1_3-1_36;2_5-2_20	50 / 56

Related Record Type Details


					3RJ6WVX57J

Lefelsiran

ACTIVE MOIETY

Interaction Type:

PRECLINICAL

Amount: