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Details

Stereochemistry ACHIRAL
Molecular Formula C20H25NO.C2H2O4
Molecular Weight 385.4535
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORMETHADONE OXALATE

SMILES

OC(=O)C(O)=O.CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=INMNKGOTEWCRST-UHFFFAOYSA-N
InChI=1S/C20H25NO.C2H2O4/c1-4-19(22)20(15-16-21(2)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;3-1(4)2(5)6/h5-14H,4,15-16H2,1-3H3;(H,3,4)(H,5,6)

HIDE SMILES / InChI
Molecular Formula C2H2O4
Molecular Weight 90.0349
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C20H25NO
Molecular Weight 295.4186
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Normethadone is a derivate of opioid analgetic methadone, used as component of antitussive drops in Canada. Illicit drug.

CNS Activity

CNS Active
3913

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Mu-type opioid receptor
61
Target ID: P33535|||Q64064
Gene ID: 25601.0
Gene Symbol: Oprm1
Target Organism: Rattus norvegicus (Rat)
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
Cophylac

Approved Use

Cough
PubMed

PubMed

TitleDatePubMed
Phenyl-substituted normethadones: synthesis and pharmacology.
1995 Mar
Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry.
2009 Apr 15

Sample Use Guides

In Vivo Use Guide
Cophylac (normethadone HCl 10 mg and p-hydroxyephedrine HCl 20 mg): 15 drops twice daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:28:50 UTC 2023
Edited
by admin
on Sat Dec 16 10:28:50 UTC 2023
Record UNII
3R57N9908J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NORMETHADONE OXALATE
Common Name English
3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, ETHANEDIOATE (1:1)
Systematic Name English
3-HEXANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, OXALATE (1:1)
Systematic Name English
6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEXANONE OXALATE
Systematic Name English
Code System Code Type Description
PUBCHEM
119025858
Created by admin on Sat Dec 16 10:28:50 UTC 2023 , Edited by admin on Sat Dec 16 10:28:50 UTC 2023
PRIMARY
CAS
6202-36-4
Created by admin on Sat Dec 16 10:28:50 UTC 2023 , Edited by admin on Sat Dec 16 10:28:50 UTC 2023
PRIMARY
FDA UNII
3R57N9908J
Created by admin on Sat Dec 16 10:28:50 UTC 2023 , Edited by admin on Sat Dec 16 10:28:50 UTC 2023
PRIMARY
Related Record Type Details
Structure of NORMETHADONE
SALT/SOLVATE -> PARENT
Structure of NORMETHADONE
PARENT -> SALT/SOLVATE
NIH
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