7-O-acetylpaclitaxel

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C47H51NO14
Molecular Weight	853.9061
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)[C@@H]4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7

InChI

InChIKey=RCINICONZNJXQF-MZXODVADSA-N

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C47H51NO14
Molecular Weight	853.9061
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	11 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.drugbank.ca/drugs/DB01229
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18068131

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. Taxol is marketed for the treatment of Breast cancer; Gastric cancer; Kaposi's sarcoma; Non-small cell lung cancer; Ovarian cancer. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis. Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer. Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
HeLa cell growth 5 Target ID: HeLa cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/27095936	Inhibitor 8504	7.08 µM [IC50]
SKOV3 breast cancer cell growth 5 Target ID: SKOV3 breast cancer cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/27599579	Inhibitor 8504	38.7 nM [IC50]
microtubule polymerization 21 Target ID: GO:0046785 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8555181	Activator 1447	23.0 µM [EC50]
Tubulin beta-1 chain 9 Target ID: CHEMBL1915 Sources: http://www.drugbank.ca/drugs/DB01229	Inhibitor 8504
Apoptosis regulator Bcl-2 19 Target ID: CHEMBL4860 Sources: http://www.drugbank.ca/drugs/DB01229	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Advanced carcinoma of the ovary 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8583	TAXOL Approved Use TAXOL is indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary. Launch Date 1998
Breast cancer 432 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8583	TAXOL Approved Use TAXOL is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Launch Date 1998
Non-small cell lung cancer 211 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8583	TAXOL Approved Use TAXOL, in combination with cisplatin, is indicated for the first-line treatment of nonsmall cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy. Launch Date 1998

C_max

Value	Dose	Co-administered	Analyte	Population
0.5 μM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/7799018	175 mg/m² steady-state, intravenous dose: 175 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN
6.92 μM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/8664192	250 mg/m² steady-state, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
27.07 μM × h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/8664192	250 mg/m² steady-state, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
14.8 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/7799018	175 mg/m² steady-state, intravenous dose: 175 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
6.5% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf			PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	Other AEs: Anaphylaxis, Dyspnea... Other AEs: Anaphylaxis (2%) Dyspnea (severe, 2%) Hypotension (severe, 2%) Generalized urticaria (severe, 2%) Angioedema (severe, 2%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf

AEs

AE	Significance	Dose	Population
Anaphylaxis	2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Angioedema	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Dyspnea	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Generalized urticaria	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Hypotension	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1741	CYP2C8 810 P-gp 2052 BCRP 697 MRP2 252 OATP1B3 435 OATP1B1 503 OATP1B2 7

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 1932	inhibitor 4027 Sources: https://www.jci.org/articles/view/15451 Page: -	no

Drug as victim

Target	Modality	Activity
CYP2C8 810	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21660_ABRAXANE_biopharmr.PDF#page=20 Page: 20.0	major
CYP3A4 1946	substrate 4014 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21660_ABRAXANE_biopharmr.PDF#page=20 Page: 20.0	minor
BCRP 697	substrate 4014 Sources: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.21013 Page: -	no
OATP1B3 435	substrate 4014 Sources: https://www.tandfonline.com/doi/abs/10.4161/cbt.4.8.1867 Page: -	yes [Km 6.79 uM]
MRP2 252	substrate 4014 Sources: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.21013 Page: -	yes
OATP1B1 503	substrate 4014 Sources: https://www.nature.com/articles/tpj201013 Page: -	yes
OATP1B2 7	substrate 4014 Sources: https://www.jci.org/articles/view/96160 Page: -	yes
P-gp 2052	substrate 4014 Sources: https://clincancerres.aacrjournals.org/content/9/7/2849.short Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:45863	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45863
ChemicalBook	CB3273425	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3273425
eMolecules	29541201	https://www.emolecules.com/cgi-bin/more?vid=29541201
eMolecules	36754358	https://www.emolecules.com/cgi-bin/more?vid=36754358
eMolecules	506301	https://www.emolecules.com/cgi-bin/more?vid=506301
MolPort	MolPort-001-742-627	https://www.molport.com/shop/molecule-link/MolPort-001-742-627
ZINC	ZINC000096006020	http://zinc15.docking.org/substances/ZINC000096006020

PubMed

Title	Date	PubMed
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.	2001-05-11	11279118
P-glycoprotein efflux pump expression and activity in Calu-3 cells.	2001-05	11288109
Taxol-induced cell cycle arrest and apoptosis: dose-response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition.	2001-04-26	11275363
Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.	2001-04-13	11278336
Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status in ovarian cancer cell lines.	2001-04-11	11295099
Regional drug delivery with radiation for the treatment of Ewing's sarcoma. In vitro development of a taxol release system.	2001-04-02	11274751
Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells.	2001-04-01	11279616
High affinity binding of paclitaxel to human serum albumin.	2001-04	11277943
Management of recurrent juvenile granulosa cell tumor of the ovary.	2001-04	11277661
Recurrent metastatic fallopian tube carcinoma in pregnancy.	2001-04	11277660
HPV16-E6 enhances mitoxantrone sensitivity in a human ovarian cancer line: an isolated instance or a trend?	2001-04	11251171
Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts.	2001-04	11241350
A paclitaxel-containing chemotherapy does not cause central nervous adverse effects: a prospective study in patients with ovarian cancer.	2001-03-28	11268500
Paclitaxel restores radiation-induced apoptosis in a bcl-2-expressing, radiation-resistant lymphoma cell line.	2001-03-15	11240255
Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers.	2001-03-12	11245908
Phase II trial of paclitaxel and carboplatin in metastatic small-cell lung cancer: a Groupe Français de Pneumo-Cancérologie study.	2001-03-01	11230474
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.	2001-03-01	11222383
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.	2001-03-01	11170102
The role of actin filaments and microtubules in hepatocyte spheroid self-assembly.	2001-03	11223949
Dynamic events are differently mediated by microfilaments, microtubules, and mitogen-activated protein kinase during porcine oocyte maturation and fertilization in vitro.	2001-03	11207204
Effects of stathmin inhibition on the mitotic spindle.	2001-03	11181174
Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol.	2001-02-22	11182049
Inhibition of telomerase activity as a measure of tumor cell killing by cisplatin in squamous cell carcinoma cell line.	2001-02-15	11173816
Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding.	2001-02-15	11170485
Phase I study of paclitaxel (Taxol) plus vinorelbine (Navelbine) in patients with untreated stage IIIb and IV non-small cell lung cancer.	2001-02-13	11165410
Cisplatin and vinorelbine as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) resistant to taxol plus gemcitabine.	2001-02-13	11165406
Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line.	2001-02-09	11162660
Biweekly gemcitabine, doxorubicin, and paclitaxel as first-line treatment in metastatic breast cancer. Final results from a phase II trial.	2001-02	11252890
Gemcitabine, paclitaxel, and trastuzumab in metastatic breast cancer.	2001-02	11252888
Gemcitabine plus cisplatin in breast cancer.	2001-02	11252886
Phytochemistry and medicinal plants.	2001-02	11243450
Membrane macrophage colony-stimulating factor on MADB106 breast cancer cells does not activate cytotoxic macrophages but immunizes rats against breast cancer.	2001-02	11237678
Isolation of cortical MTs from tobacco BY-2 cells.	2001-02	11230570
Selective drug resistant human osteosarcoma cell lines.	2001-02	11210963
Changes in glycosylation during Drosophila development. The influence of ecdysone on hemomucin isoforms.	2001-02	11164341
Disruption of microtubular cytoskeleton induced by cryptogein, an elicitor of hypersensitive response in tobacco cells.	2001-02	11161014
Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	2001-02	11160861
Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum.	2001-01-23	11164964
Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels.	2001-01-15	11212279
Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity.	2001-01-15	11212270
Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel.	2001-01-15	11212244
Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.	2001-01-04	11244509
Treatment of non-small-cell lung cancer in North America: the emerging role of irinotecan.	2001-01	11221017
Neurotoxicity associated with a regimen of carboplatin (AUC 5-6) and paclitaxel (175 mg/m2 over 3 h) employed in the treatment of gynecologic malignancies.	2001-01	11206272
Tumor cell-derived TGF-beta and IL-10 dysregulate paclitaxel-induced macrophage activation.	2001-01	11200057
Colchicine and griseofulvin inhibit VCAM-1 expression on human vascular endothelial cells - evidence for the association of VCAM-1 expression with microtubules.	2001-01	11154858
Doxorubicin and paclitaxel in the treatment of advanced breast cancer: efficacy and cardiac considerations.	2001	11296620
The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m2 continuous infusion over 24 h) with hematopoietic support in women with metastatic breast cancer.	2001	11221961
Drug approval summaries: arsenic trioxide, tamoxifen citrate, anastrazole, paclitaxel, bexarotene.	2001	11161223
Phase II clinical trials of cisplatin-then-paclitaxel and paclitaxel-then-cisplatin in patients with previously untreated advanced epithelial ovarian cancer.	2000-12	11205470

Patents

Sample Use Guides

In Vivo Use Guide

For previously untreated patients with carcinoma of the ovary, one of the following recommended regimens may be given every 3 weeks. a.TAXOL (PACLITAXEL) administered intravenously over 3 hours at a dose of 175 mg/m2 followed by cisplatin at a dose of 75 mg/m2; or b.TAXOL (PACLITAXEL) administered intravenously over 24 hours at a dose of 135 mg/m2 followed by cisplatin at a dose of 75 mg/m2 2) In patients previously treated with chemotherapy for carcinoma of the ovary, the recommended regimen is TAXOL (PACLITAXEL) 135 mg/m2 or 175 mg/m2 administered intravenously over 3 hours every 3 weeks.

Route of Administration: Intravenous

In Vitro Use Guide

Paclitaxel inhibited tubulin polymerization in the presence of MAPs in vitro with an IC50 value of 38.19 ± 3.33 uM in living cancer cells (Hela cells and human osteosarcoma U2OS cells).

Substance Class	Chemical Created by `admin` on `Wed Apr 02 15:48:20 GMT 2025` Edited by `admin` on `Wed Apr 02 15:48:20 GMT 2025`
Record UNII	3PPC5TL76P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

7-O-acetylpaclitaxel

Common Name

English

7-Acetyltaxol

Preferred Name

English

Benzenepropanoic acid, ?-(benzoylamino)-?-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6,12b-tris(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b

Systematic Name

English

4,7?,10?-tris(acetyloxy)-13?-[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-5?,20-epoxytax-11-en-2?-yl benzoate

Systematic Name

English

Benzenepropanoic acid, ?-(benzoylamino)-?-hydroxy-, 4,6,12b-tris(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2a?,4?,4a?,6?

Systematic Name

English

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-4,6,12b-Tris(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (?R,?S)-?-(benzoylamino)-?-hydroxybenzene

Systematic Name

English

PACLITAXEL IMPURITY L [EP IMPURITY]

Common Name

English

Code System Code Type Description

PUBCHEM

36314

Created by admin on Wed Apr 02 15:48:20 GMT 2025 , Edited by admin on Wed Apr 02 15:48:20 GMT 2025

PRIMARY

CAS

92950-39-5

Created by admin on Wed Apr 02 15:48:20 GMT 2025 , Edited by admin on Wed Apr 02 15:48:20 GMT 2025

PRIMARY

FDA UNII

3PPC5TL76P

Created by admin on Wed Apr 02 15:48:20 GMT 2025 , Edited by admin on Wed Apr 02 15:48:20 GMT 2025

PRIMARY

SMS_ID

300000053031

Created by admin on Wed Apr 02 15:48:20 GMT 2025 , Edited by admin on Wed Apr 02 15:48:20 GMT 2025

PRIMARY

Related Record Type Details


					P88XT4IS4D

PACLITAXEL

PARENT -> IMPURITY

Amount:

Details

SMILES

InChI

DescriptionSources: http://www.drugbank.ca/drugs/DB01229Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18068131

CNS Activity

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Launch Date

Approved Use

Launch Date

Cmax

AUC

T1/2

Funbound

Doses

AEs

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: http://www.drugbank.ca/drugs/DB01229
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18068131

C_max

T_1/2

F_unbound

Drug as perpetrator