AZD-7624

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H30FN5O3
Molecular Weight	491.5572
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCOC1=CC=CC=C1C2(CC2)NC3=NC=CN(C3=O)C4=C(C)C(F)=CC(=C4)C(=O)NC5CC5

InChI

InChIKey=NNKPHNTWNILINE-UHFFFAOYSA-N

InChI=1S/C27H30FN5O3/c1-17-21(28)15-18(25(34)31-19-7-8-19)16-22(17)33-13-11-30-24(26(33)35)32-27(9-10-27)20-5-3-4-6-23(20)36-14-12-29-2/h3-6,11,13,15-16,19,29H,7-10,12,14H2,1-2H3,(H,30,32)(H,31,34)

HIDE SMILES / InChI

Molecular Formula	C27H30FN5O3
Molecular Weight	491.5572
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Analyte	Population
56.05 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	200 μg single, respiratory dose: 200 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
76.93 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	400 μg single, respiratory dose: 400 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
430.8 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	1600 μg single, respiratory dose: 1600 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
164.3 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	200 μg 1 times / day steady-state, respiratory dose: 200 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
261.2 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	400 μg 1 times / day steady-state, respiratory dose: 400 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1206 pM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	1600 μg 1 times / day steady-state, respiratory dose: 1600 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
1314 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	200 μg single, respiratory dose: 200 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2736 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	400 μg single, respiratory dose: 400 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
13960 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	1600 μg single, respiratory dose: 1600 μg route of administration: Respiratory experiment type: SINGLE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
2426 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	200 μg 1 times / day steady-state, respiratory dose: 200 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
4409 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	400 μg 1 times / day steady-state, respiratory dose: 400 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
20830 pM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	1600 μg 1 times / day steady-state, respiratory dose: 1600 μg route of administration: Respiratory experiment type: STEADY-STATE co-administered:	AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
39.88 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	200 μg single, respiratory dose: 200 μg route of administration: Respiratory experiment type: SINGLE co-administered:		AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
43.57 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31814707/	1600 μg single, respiratory dose: 1600 μg route of administration: Respiratory experiment type: SINGLE co-administered:		AZD-7624 plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:59:05 GMT 2025` Edited by `admin` on `Mon Mar 31 21:59:05 GMT 2025`
Record UNII	3P4CR02JTD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-7624

Code

English

AZD 7624 [WHO-DD]

Preferred Name

English

N-CYCLOPROPYL-3-FLUORO-4-METHYL-5-(3-((1-(2-(2-(METHYLAMINO)ETHOXY)PHENYL)CYCLOPROPYL)AMINO)-2-OXOPYRAZIN-1(2H)-YL)BENZAMIDE

Systematic Name

English

BENZAMIDE, N-CYCLOPROPYL-3-FLUORO-4-METHYL-5-(3-((1-(2-(2-(METHYLAMINO)ETHOXY)PHENYL)CYCLOPROPYL)AMINO)-2-OXO-1(2H)-PYRAZINYL)-

Systematic Name

English

Code System Code Type Description

SMS_ID

100000174865