CUPRIC SALICYLATE TETRAHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C7H5O3.Cu.4H2O
Molecular Weight	409.833
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CUPRIC SALICYLATE TETRAHYDRATE

Structure Search

SMILES

O.O.O.O.[Cu++].OC1=CC=CC=C1C([O-])=O.OC2=CC=CC=C2C([O-])=O

InChI

InChIKey=IMGUOQFRYIAXGF-UHFFFAOYSA-L

InChI=1S/2C7H6O3.Cu.4H2O/c2*8-6-4-2-1-3-5(6)7(9)10;;;;;/h2*1-4,8H,(H,9,10);;4*1H2/q;;+2;;;;/p-2

HIDE SMILES / InChI

Molecular Formula	C7H6O3
Molecular Weight	138.1207
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Cu
Molecular Weight	63.546
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963

Cupric salicylate is an anti-inflammatory agent which was used as pain relief for patients with osteoarthritis, rheumatoid and other degenerative diseases (as a copper-salicylate complex). The preparation seem to be discontinued for now.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatic diseases 31 Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963	Palliative		Approved 8583	PERMALON Approved Use Unknown

PubMed

Title	Date	PubMed
The effect of ionic strength on the complexation of copper (II) with salicylate ion.	2002-07-20	12125457
Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.	1997-08-04	9269267
Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats.	1983-02-28	6600809
Treatment of rheumatoid and degenerative diseases with copper complexes: a review with emphasis on copper-salicylate.	1977-09	367963

Patents

Sample Use Guides

In Vivo Use Guide

Cupric salicylate gel (1.5 g) was applied twice daily to the forearm for four weeks. Cupric salicylate also was given as 6 and 8 intravenous infusions (60-80 mg of copper, Permalon preparation) every 3-4 days.

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:18:06 GMT 2025` Edited by `admin` on `Mon Mar 31 21:18:06 GMT 2025`
Record UNII	3NAB6I41LP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENZOIC ACID, 2-HYDROXY-, COPPER(2+) SALT (2:1), TETRAHYDRATE

Preferred Name

English

CUPRIC SALICYLATE TETRAHYDRATE

Common Name

English

COPPER, BIS(SALICYLATO)-, TETRAHYDRATE

Common Name

English

COPPER, BIS(2-(HYDROXY-.KAPPA.O)BENZOATO-.KAPPA.O)-, TETRAHYDRATE

Common Name

English

CUPRIC SALICYLATE TETRAHYDRATE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

3NAB6I41LP