CUPRIC SALICYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C7H5O3.Cu
Molecular Weight	337.772
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cu++].OC1=CC=CC=C1C([O-])=O.OC2=CC=CC=C2C([O-])=O

InChI

InChIKey=CMRVDFLZXRTMTH-UHFFFAOYSA-L

InChI=1S/2C7H6O3.Cu/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula	Cu
Molecular Weight	63.546
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H5O3
Molecular Weight	137.1128
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963

Cupric salicylate is an anti-inflammatory agent which was used as pain relief for patients with osteoarthritis, rheumatoid and other degenerative diseases (as a copper-salicylate complex). The preparation seem to be discontinued for now.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatic diseases 30 Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963	Palliative		Approved 8429	PERMALON Approved Use Unknown

PubMed

Title	Date	PubMed
Treatment of rheumatoid and degenerative diseases with copper complexes: a review with emphasis on copper-salicylate.	1977 Sep	367963
Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats.	1983 Feb 28	6600809
Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.	1997 Aug 4	9269267
The effect of ionic strength on the complexation of copper (II) with salicylate ion.	2002 May-Jun	12125457

Patents

Sample Use Guides

In Vivo Use Guide

Cupric salicylate gel (1.5 g) was applied twice daily to the forearm for four weeks. Cupric salicylate also was given as 6 and 8 intravenous infusions (60-80 mg of copper, Permalon preparation) every 3-4 days.

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:59:20 GMT 2023` Edited by `admin` on `Sat Dec 16 03:59:20 GMT 2023`
Record UNII	I11SQ4NX1R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CUPRIC SALICYLATE

Common Name

English

Copper salicylate [WHO-DD]

Common Name

English

BIS(2-(HYDROXY-.KAPPA.O)BENZOATO-.KAPPA.O)COPPER

Common Name

English

BENZOIC ACID, 2-HYDROXY-, COPPER(2+) SALT

Common Name

English

COPPER(II) SALICYLATE

Systematic Name

English

COPPER, BIS(2-HYDROXYBENZOATO-O1,O2)-

Common Name

English

COPPER DISALICYLATE

Systematic Name

English

2-HYDROXYBENZOIC ACID COPPER SALT

Common Name

English

COPPER(2+) SALICYLATE

Systematic Name

English

CUPRIC O-HYDROXYBENZOATE

Common Name

English

CUPRIC SALICYLATE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

I11SQ4NX1R