| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H34O2 |
| Molecular Weight | 318.4935 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
InChIKey=AURFZBICLPNKBZ-GRWISUQFSA-N
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16+,17-,18+,19+,20+,21-/m1/s1
| Molecular Formula | C21H34O2 |
| Molecular Weight | 318.4935 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Epipregnanolone is an epimer of endogenous neurosteroid pregnanolone, it has been shown to antagonize GABAA and NMDA receptors. In addition epipregnanolone inhibits calcium T-currents and stimulates TRPM3 channel. Epipregnanolone displays anesthetic properties. Epipregnanolone has been shown to reduce alcohol self-administration in rats.
CNS Activity
Approval Year
PubMed
Sample Use Guides
Intraperitoneal epipregnanolone (5, 10, and 20 mg/kg) dose-dependently attenuated ethanol self-administration in rats.
Intraplantar injections (0.1, 1 or 10 uM) of epipregnanolone directly into peripheral receptive fields reduced responses to nociceptive stimuli in rodents in a dose-dependent fashion.
Route of Administration:
Other
