BICISATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H24N2O4S2
Molecular Weight	324.46
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)[C@H](CS)NCCN[C@@H](CS)C(=O)OCC

InChI

InChIKey=RZQNBTMGBODDSK-UWVGGRQHSA-N

InChI=1S/C12H24N2O4S2/c1-3-17-11(15)9(7-19)13-5-6-14-10(8-20)12(16)18-4-2/h9-10,13-14,19-20H,3-8H2,1-2H3/t9-,10-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C12H24N2O4S2
Molecular Weight	324.46
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.drugs.com/pro/neurolite.html

Bicisate hydrochloride is a ligand that is used to form a complex with technetium. Tc99m Bicisate forms a stable, lipophilic complex that crosses intact cell membranes and blood brain barrier by passive diffusion. The amount of tc99m bicisate is stable in the brain until about 6 hours. Tc99m bicisate is indicated as an adjunct to conventional CT or MRI imaging in the localization of stroke in patients in whom stroke has already been diagnosed.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Stroke 144 Sources: https://www.drugs.com/pro/neurolite.html	Diagnostic		Approved 8429	NEUROLITE Approved Use Tc99m bicisate is indicated as an adjunct to conventional CT or MRI imaging in the localization of stroke in patients in whom stroke has already been diagnosed Launch Date 1994

PubMed

Title	Date	PubMed
Brain SPECT imaging and psychiatry.	1992 Nov	1459983
99mTc-bicisate reliably images CBF in chronic brain diseases but fails to show reflow hyperemia in subacute stroke: report of a multicenter trial of 105 cases comparing 133Xe and 99mTc-bicisate (ECD, neurolite) measured by SPECT on same day.	1994 Jan	8263071
99mTc-bicisate (neurolite) SPECT brain imaging and cognitive impairment in dementia of the Alzheimer type: a blinded read of image sets from a multicenter SPECT trial.	1994 Jan	8263078

Patents

Sample Use Guides

In Vivo Use Guide

This drug is administered by intravenous injection for diagnostic use after reconstitution with sterile, non-pyrogenic, oxidant-free Sodium Pertechnetate Tc99m Injection.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:20:30 GMT 2023` Edited by `admin` on `Fri Dec 15 16:20:30 GMT 2023`
Record UNII	3JXF0Z0XOI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BICISATE

Common Name

English

L-CYSTEINE, N,N'-1,2-ETHANEDIYLBIS-, DIETHYL ESTER

Common Name

English

Bicisate [WHO-DD]

Common Name

English

DIETHYL (2R,2'R)-2,2'-(ETHANE-1,2-DIYLDIIMINO)BIS(3-MERCAPTOPROPANOATE)

Systematic Name

English

L-CYSTEINE, N,N'-1,2-ETHANEDIYLBIS-, 1,1'-DIETHYL ESTER

Common Name

English

Code System Code Type Description

RXCUI

1306100