U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C15H19NO.C6H13NO3S
Molecular Weight 408.555
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FURFENOREX CYCLAMATE

SMILES

OS(=O)(=O)NC1CCCCC1.CC(CC2=CC=CC=C2)N(C)CC3=CC=CO3

InChI

InChIKey=AVANVRBQOCVTLV-UHFFFAOYSA-N
InChI=1S/C15H19NO.C6H13NO3S/c1-13(11-14-7-4-3-5-8-14)16(2)12-15-9-6-10-17-15;8-11(9,10)7-6-4-2-1-3-5-6/h3-10,13H,11-12H2,1-2H3;6-7H,1-5H2,(H,8,9,10)

HIDE SMILES / InChI
Molecular Formula C6H13NO3S
Molecular Weight 179.237
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C15H19NO
Molecular Weight 229.3175
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Furfenorex (unde brand name Frugalan), was used against obesity as an appetite suppressant. One of its metabolite was metamphetamine, which lead to the abuse to the drug. That is why this drug is no longer marketed

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Not Provided
511
FRUGALAN

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results.
2002-05
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.
2002-04
[Clinical study of a new anorexigen: E-106-E (Frugalan Diamant)].
1967-05-28
[Pharmacologic study of an anorexigenic agent: furfenorex].
1967-05
Patents

Patents

US20150185124
2
WO2010015029A1
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:48:18 GMT 2025
Edited
by admin
on Mon Mar 31 21:48:18 GMT 2025
Record UNII
3I528CI6MM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FURFENOREX CYCLAMATE
Common Name English
FURFURYLMETHYLAMPHETAMINE D-FORM CYCLOHEXYLSULFAMATE
MI  
Preferred Name English
FURFURYLMETHYLAMPHETAMINE D-FORM CYCLOHEXYLSULFAMATE [MI]
Common Name English
E-106-E
Code English
FURFENOREX CYCLAMATE, (+)-
Common Name English
SD-27115
Code English
FURFENOREX CYCLOHEXYLSULFAMATE, (+)-
Common Name English
SULFAMIC ACID, CYCLOHEXYL-, COMPD. WITH (+)-N-METHYL-N-(1-METHYL-2-PHENYLETHYL)-2-FURANMETHANAMINE (1:1)
Systematic Name English
SD 27115
Code English
Code System Code Type Description
CAS
3776-92-9
Created by admin on Mon Mar 31 21:48:18 GMT 2025 , Edited by admin on Mon Mar 31 21:48:18 GMT 2025
PRIMARY
ECHA (EC/EINECS)
223-232-6
Created by admin on Mon Mar 31 21:48:18 GMT 2025 , Edited by admin on Mon Mar 31 21:48:18 GMT 2025
PRIMARY
FDA UNII
3I528CI6MM
Created by admin on Mon Mar 31 21:48:18 GMT 2025 , Edited by admin on Mon Mar 31 21:48:18 GMT 2025
PRIMARY
MERCK INDEX
m195
Created by admin on Mon Mar 31 21:48:18 GMT 2025 , Edited by admin on Mon Mar 31 21:48:18 GMT 2025
PRIMARY Merck Index
Related Record Type Details
Structure of FURFENOREX
PARENT -> SALT/SOLVATE
Structure of FURFENOREX CYCLAMATE, (±)-
RACEMATE -> ENANTIOMER
Related Record Type Details
Structure of FURFENOREX
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966