ELINAFIDE BISMESYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C31H28N4O4.2CH4O3S
Molecular Weight	712.79
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CS(O)(=O)=O.O=C1N(CCNCCCNCCN2C(=O)C3=CC=CC4=CC=CC(C2=O)=C34)C(=O)C5=C6C(C=CC=C16)=CC=C5

InChI

InChIKey=ZDEINNOMAWXNKF-UHFFFAOYSA-N

InChI=1S/C31H28N4O4.2CH4O3S/c36-28-22-10-1-6-20-7-2-11-23(26(20)22)29(37)34(28)18-16-32-14-5-15-33-17-19-35-30(38)24-12-3-8-21-9-4-13-25(27(21)24)31(35)39;2*1-5(2,3)4/h1-4,6-13,32-33H,5,14-19H2;2*1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C31H28N4O4
Molecular Weight	520.5784
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12651198
Curator's Comment: description was created based on several sources, including: http://grantome.com/grant/NIH/M01-RR000080-40-1031 | http://adisinsight.springer.com/drugs/800005099 | https://www.ncbi.nlm.nih.gov/pubmed/7867004

Elinafide (LU 79553) is a bisintercalating naphthalamide and a topoisomerase II inhibitor has demonstrated a higher binding affinity for DNA and significant antitumour efficacy against a panel of established tumour cell lines, including several multidrug resistant-positive sublines. Elinafide had been in phase II clinical trial for the treatment of ovarian cancer and phase I trials for the treatment of various solid tumours. The major haematological toxicities observed were anaemia and neutropenia. The major non-haematological toxicities observed in the 3-weekly schedule were neuro-muscular presenting clinically as a mixed syndrome of severe weakness (sometimes with pain in both legs), myalgia and arthralgia, asthenia/fatigue/malaise. One fatality was considered related to LU 79553, as the patient had fever and neutropenia. Clinical study of this drug candidate was discontinued due to its neuromuscular dose-limiting toxicity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase II 66 Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7867004	Inhibitor 8504		18.0 µM [IC50]
DNA 282 Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10563793 \| https://www.ncbi.nlm.nih.gov/pubmed/10563793 \| https://www.ncbi.nlm.nih.gov/pubmed/19449871	Binding Agent 1076

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ovarian cancer 160 Sources: http://grantome.com/grant/NIH/M01-RR000080-40-1031	Primary		Phase II 1147	Unknown Approved Use Unknown
Solid tumors 147 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11157040	Primary		Phase I 438	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
294.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	24 mg/m² 1 times / day multiple, intravenous dose: 24 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
105.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	6.6 mg/m² 1 times / day multiple, intravenous dose: 6.6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
22.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	2 mg/m² 1 times / day multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
74 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	14 mg/m² 1 times / day multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
177.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	18 mg/m² 1 times / day multiple, intravenous dose: 18 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
47.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	4 mg/m² 1 times / day multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
177.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	10 mg/m² 1 times / day multiple, intravenous dose: 10 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
1357.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	24 mg/m² 1 times / day multiple, intravenous dose: 24 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
384.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	6.6 mg/m² 1 times / day multiple, intravenous dose: 6.6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
123 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	2 mg/m² 1 times / day multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
658.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	14 mg/m² 1 times / day multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
978.7 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	18 mg/m² 1 times / day multiple, intravenous dose: 18 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
238 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	4 mg/m² 1 times / day multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
620.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	10 mg/m² 1 times / day multiple, intravenous dose: 10 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
54.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	24 mg/m² 1 times / day multiple, intravenous dose: 24 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
42.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	6.6 mg/m² 1 times / day multiple, intravenous dose: 6.6 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
39.8 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	2 mg/m² 1 times / day multiple, intravenous dose: 2 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
36 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	14 mg/m² 1 times / day multiple, intravenous dose: 14 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
37.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	18 mg/m² 1 times / day multiple, intravenous dose: 18 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
37.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	4 mg/m² 1 times / day multiple, intravenous dose: 4 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
44.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/11157040	10 mg/m² 1 times / day multiple, intravenous dose: 10 mg/m² route of administration: Intravenous experiment type: MULTIPLE co-administered:	ELINAFIDE plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
120 mg/m2 1 times / 3 weeks multiple, intravenous MTD Dose: 120 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 120 mg/m2, 1 times / 3 weeks Sources: https://pubmed.ncbi.nlm.nih.gov/12651198	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/12651198	DLT: neuro-muscular toxicity... Dose limiting toxicities: neuro-muscular toxicity (grade 3, 3 patients) Sources: https://pubmed.ncbi.nlm.nih.gov/12651198

AEs

AE	Significance	Dose	Population
neuro-muscular toxicity	grade 3, 3 patients DLT	120 mg/m2 1 times / 3 weeks multiple, intravenous MTD Dose: 120 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 120 mg/m2, 1 times / 3 weeks Sources: https://pubmed.ncbi.nlm.nih.gov/12651198	unhealthy Health Status: unhealthy Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/12651198

Sourcing

Vendor/Aggregator	ID	URL
BOC Sciences	162706-37-8	http://www.bocsci.com/description.asp?cas=162706-37-8
eMolecules	110013437	https://orderbb.emolecules.com/search/#?query=110013437
MuseChem	M036857	https://www.musechem.com/product/M036857.html
Synchem UG and Co KG	fd013de11	https://www.synchem.de/?s=fd013de11&post_type=product
Synchem UG and Co KG	un371	https://www.synchem.de/?s=un371&post_type=product

PubMed

Title	Date	PubMed
Analysis of mixed DNA-bisnaphthalimide interactions involving groove association and intercalation with surface-based and solution methodologies.	2012-12	22987588
Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides.	2011-09-15	21880496
Indirect effects modulating the interaction between DNA and a cytotoxic bisnaphthalimide reveal a two-step binding process.	2009-06-10	19449871
New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.	2004-03-11	14998328

Patents

Sample Use Guides

In Vivo Use Guide

100 mg/m(2)/course (60 min infusion in 500 ml normal saline) (3-weekly regimen)

Route of Administration: Intravenous

In Vitro Use Guide

LU 79553 was tested in a cytotoxicity assay against a panel of human and murine cell lines. LU 79553 inhibited the growth of all cell lines tested, with EC50 values ranging from 2x10(-7) to 5x10(-10) M.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:07:42 GMT 2025` Edited by `admin` on `Mon Mar 31 18:07:42 GMT 2025`
Record UNII	3FC3K5CEP1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1H-BENZ(DE)ISOQUINOLINE-1,3(2H)-DIONE, 2,2'-(1,3-PROPANEDIYLBIS(IMINO-2,1-ETHANEDIYL))BIS-, DIMETHANESULFONATE

Preferred Name

English

ELINAFIDE BISMESYLATE

Common Name

English

Code System Code Type Description

FDA UNII

3FC3K5CEP1

Created by admin on Mon Mar 31 18:07:42 GMT 2025 , Edited by admin on Mon Mar 31 18:07:42 GMT 2025

PRIMARY

CAS

199330-45-5

Created by admin on Mon Mar 31 18:07:42 GMT 2025 , Edited by admin on Mon Mar 31 18:07:42 GMT 2025

PRIMARY

PUBCHEM

87307580

Created by admin on Mon Mar 31 18:07:42 GMT 2025 , Edited by admin on Mon Mar 31 18:07:42 GMT 2025

PRIMARY

CAS

162706-57-2

Created by admin on Mon Mar 31 18:07:42 GMT 2025 , Edited by admin on Mon Mar 31 18:07:42 GMT 2025

NON-SPECIFIC STOICHIOMETRY

Related Record Type Details


					HL580335SI

ELINAFIDE

PARENT -> SALT/SOLVATE

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/12651198Curator's Comment: description was created based on several sources, including: http://grantome.com/grant/NIH/M01-RR000080-40-1031 | http://adisinsight.springer.com/drugs/800005099 | https://www.ncbi.nlm.nih.gov/pubmed/7867004

Originator

Approval Year

Targets

Conditions

Approved Use

Approved Use

Cmax

AUC

T1/2

Doses

AEs

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12651198
Curator's Comment: description was created based on several sources, including: http://grantome.com/grant/NIH/M01-RR000080-40-1031 | http://adisinsight.springer.com/drugs/800005099 | https://www.ncbi.nlm.nih.gov/pubmed/7867004

C_max

T_1/2