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Details

Stereochemistry ABSOLUTE
Molecular Formula C27H48O6
Molecular Weight 468.6664
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NOBIPROSTOLAN

SMILES

CCCCCCCC2(CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C\CCCC(=O)OC(C)C)OCCO2

InChI

InChIKey=FCDDMESBMCWDJP-PEEJLGBMSA-N
InChI=1S/C27H48O6/c1-4-5-6-9-12-16-27(31-18-19-32-27)17-15-23-22(24(28)20-25(23)29)13-10-7-8-11-14-26(30)33-21(2)3/h7,10,21-25,28-29H,4-6,8-9,11-20H2,1-3H3/b10-7+/t22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula C27H48O6
Molecular Weight 468.6664
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 1
Optical Activity UNSPECIFIED

Description

Mallinckrodt (previously Sucampo Pharmaceuticals) is developing nobiprostolan (RK 023), a topical therapy for male pattern baldness (androgenetic alopecia) and hypotrichosis. The drug is a physiologically active fatty acid derivative. Nobiprostolan is in Phase IIa clinical trials for the treatment of male pattern baldness.

Originator

Approval Year

Sample Use Guides

In Vivo Use Guide
RK-023 was applied 2 mL each to a hair-thinning part of scalp twice daily in the patients with androgenetic alopecia.
Route of Administration: Topical
Substance Class Chemical
Record UNII
3AF610ZQ3R
Record Status Validated (UNII)
Record Version