U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C28H40N2O5
Molecular Weight 484.6276
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GALLOPAMIL

SMILES

COC1=CC(=CC(OC)=C1OC)C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C

InChI

InChIKey=XQLWNAFCTODIRK-UHFFFAOYSA-N
InChI=1S/C28H40N2O5/c1-20(2)28(19-29,22-17-25(33-6)27(35-8)26(18-22)34-7)13-9-14-30(3)15-12-21-10-11-23(31-4)24(16-21)32-5/h10-11,16-18,20H,9,12-15H2,1-8H3

HIDE SMILES / InChI

Molecular Formula C28H40N2O5
Molecular Weight 484.6276
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Gallopamil is a L-type calcium channel blocker designed for the treatment of coronary heart diseases: angina pectoris, prinzmetal angina and hypertonia.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
5.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROCORUM
Primary
PROCORUM
Primary
PROCORUM

PubMed

Sample Use Guides

In Vivo Use Guide
150 mg/day
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
39WPC8JHR8
Record Status Validated (UNII)
Record Version