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Details

Stereochemistry ABSOLUTE
Molecular Formula C51H62N12O7
Molecular Weight 955.1142
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GROWTH HORMONE-RELEASING PEPTIDE 1

SMILES

C[C@H](N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CNC5=C4C=CC=C5)C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N[C@@H](CCCCN)C(N)=O

InChI

InChIKey=NWQWNCILOXTTHF-HLCSKTDOSA-N
InChI=1S/C51H62N12O7/c1-30(53)46(65)60-44(26-37-28-55-29-57-37)51(70)63-42(24-33-19-20-34-14-6-7-15-35(34)22-33)48(67)58-31(2)47(66)61-43(25-36-27-56-39-17-9-8-16-38(36)39)50(69)62-41(23-32-12-4-3-5-13-32)49(68)59-40(45(54)64)18-10-11-21-52/h3-9,12-17,19-20,22,27-31,40-44,56H,10-11,18,21,23-26,52-53H2,1-2H3,(H2,54,64)(H,55,57)(H,58,67)(H,59,68)(H,60,65)(H,61,66)(H,62,69)(H,63,70)/t30-,31-,40-,41+,42+,43-,44-/m0/s1

HIDE SMILES / InChI

Molecular Formula C51H62N12O7
Molecular Weight 955.1142
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 7 / 7
E/Z Centers 0
Optical Activity UNSPECIFIED

GHRP-1 is a growth hormone releasing peptide. GHRPs are synthetic, non-natural peptides that stimulate secretion of endogenous growth hormone. Like other GHRPs, the synthetic met-enkephalin analogue GHRP-1 includes unnatural D-amino acids, and was designed for its ability to stimulate growth hormone release, and may serve as performance enhancing drug. GHRP-1 is banned by the World Anti-Doping Agency, and can be detected using urine tests. The compound is thought to be a weaker stimulant of GH secretion than growth hormone-releasing hormone (GHRH). In an in vivo study in sheep it was shown that GHRP-1 and GHRH behave differently. Animals that exhibited a stronger reaction to GHRP-1, showed a weaker reaction to GHRH and vice-versa. This possibly reflects differences in intracellular mechanisms at the pituitary level.

Approval Year

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:47:43 GMT 2023
Edited
by admin
on Fri Dec 15 15:47:43 GMT 2023
Record UNII
39EVI31P0W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GROWTH HORMONE-RELEASING PEPTIDE 1
Common Name English
GHRP-1
Common Name English
ALA-HIS-3-(2-NAPHTHALENYL)-D-ALA-ALA-TRP-D-PHE-LYS-NH2
Common Name English
L-ALANYL-L-HISTIDYL-3-(2-NAPHTHALENYL)-D-ALANYL-L-ALANYL-L-TRYPTOPHYL-D-PHENYLALANYL-L-LYSINAMIDE
Systematic Name English
Code System Code Type Description
FDA UNII
39EVI31P0W
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
PUBCHEM
10350910
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
CAS
141925-59-9
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
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