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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H14N2O6
Molecular Weight 258.228
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2'-O-METHYLURIDINE

SMILES

CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(=O)NC2=O

InChI

InChIKey=SXUXMRMBWZCMEN-ZOQUXTDFSA-N
InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

HIDE SMILES / InChI

Molecular Formula C10H14N2O6
Molecular Weight 258.228
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: 2'-O-methyluridine hydrolase (E. coli)
PubMed

PubMed

TitleDatePubMed
Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly.
2015 Aug 25
A novel nucleoside hydrolase from Lactobacillus buchneri LBK78 catalyzing hydrolysis of 2'-O-methylribonucleosides.
2016 Aug
ADME studies of [5-(3)H]-2'-O-methyluridine nucleoside in mice: a building block in siRNA therapeutics.
2016 Feb
Enzymatic synthesis of 2'-O-methylribonucleosides with a nucleoside hydrolase family enzyme from Lactobacillus buchneri LBK78.
2017 Jun
Osmium Tag for Post-transcriptionally Modified RNA.
2018 Aug 6
New nucleoside hydrolase with transribosylation activity from Agromyces sp. MM-1 and its application for enzymatic synthesis of 2'-O-methylribonucleosides.
2018 Jan
Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries.
2018 Nov 7
Structural and Energetic Effects of O2'-Ribose Methylation of Protonated Pyrimidine Nucleosides.
2019 Nov
Distinct Modified Nucleosides in tRNA(Trp) from the Hyperthermophilic Archaeon Thermococcus kodakarensis and Requirement of tRNA m(2)G10/m(2)(2)G10 Methyltransferase (Archaeal Trm11) for Survival at High Temperatures.
2019 Nov 1
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:29:28 GMT 2023
Edited
by admin
on Sat Dec 16 10:29:28 GMT 2023
Record UNII
399VZB6TMB
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2'-O-METHYLURIDINE
Systematic Name English
O2'-METHYLURIDINE
Systematic Name English
URIDINE, 2'-O-METHYL-
Systematic Name English
Code System Code Type Description
PUBCHEM
102212
Created by admin on Sat Dec 16 10:29:28 GMT 2023 , Edited by admin on Sat Dec 16 10:29:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID10943959
Created by admin on Sat Dec 16 10:29:28 GMT 2023 , Edited by admin on Sat Dec 16 10:29:28 GMT 2023
PRIMARY
FDA UNII
399VZB6TMB
Created by admin on Sat Dec 16 10:29:28 GMT 2023 , Edited by admin on Sat Dec 16 10:29:28 GMT 2023
PRIMARY
CAS
2140-76-3
Created by admin on Sat Dec 16 10:29:28 GMT 2023 , Edited by admin on Sat Dec 16 10:29:28 GMT 2023
PRIMARY
CHEBI
19227
Created by admin on Sat Dec 16 10:29:28 GMT 2023 , Edited by admin on Sat Dec 16 10:29:28 GMT 2023
PRIMARY