Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H20F3N5O |
| Molecular Weight | 427.4223 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC=C(N=C1C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(=O)N4CCNCC4
InChI
InChIKey=GGOFGCMPKAWHEZ-UHFFFAOYSA-N
InChI=1S/C22H20F3N5O/c23-22(24,25)17-7-5-15(6-8-17)19-20(26)28-13-18(29-19)14-1-3-16(4-2-14)21(31)30-11-9-27-10-12-30/h1-8,13,27H,9-12H2,(H2,26,28)
| Molecular Formula | C22H20F3N5O |
| Molecular Weight | 427.4223 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:37:23 GMT 2023
by
admin
on
Sat Dec 16 16:37:23 GMT 2023
|
| Record UNII |
393V9PB5QE
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Code | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
71711915
Created by
admin on Sat Dec 16 16:37:24 GMT 2023 , Edited by admin on Sat Dec 16 16:37:24 GMT 2023
|
PRIMARY | |||
|
393V9PB5QE
Created by
admin on Sat Dec 16 16:37:24 GMT 2023 , Edited by admin on Sat Dec 16 16:37:24 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
BINDER->LIGAND |
BINDING
|
||
|
TARGET ORGANISM->INHIBITOR |
Potency against clinical isolates from Papua, Indonesia, was significantly higher than that of
MMV048 in P. vivax and in P. falciparum.
|
||
|
TARGET ORGANISM->INHIBITOR |
Potency against clinical isolates from Papua, Indonesia, was significantly higher than that of
MMV048 in P. vivax and in P. falciparum.
IC50
|
||
|
TARGET ORGANISM->INHIBITOR |
Whole-cell blood stage activity of UCT943 against a panel of resistant P. falciparum strains to determine potential for cross-resistance compared with MMV048, chloroquine (CQ) and artesunate (AS)
|
