EXIFONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H10O7
Molecular Weight	278.2143
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=CC=C(C(=O)C2=CC(O)=C(O)C(O)=C2)C(O)=C1O

InChI

InChIKey=XEDWWPGWIXPVRQ-UHFFFAOYSA-N

InChI=1S/C13H10O7/c14-7-2-1-6(11(18)13(7)20)10(17)5-3-8(15)12(19)9(16)4-5/h1-4,14-16,18-20H

HIDE SMILES / InChI

Molecular Formula	C13H10O7
Molecular Weight	278.2143
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2737393 | https://www.ncbi.nlm.nih.gov/pubmed/2807130

Exifone, a drug recently proposed for the treatment of cognitive deficiencies of old age, has been marketed in France beginning in April 1988. It demonstrated remarkable anti-radical properties, but was withdrawal, because of the hepatotoxicity.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's disease 232 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3286439	Primary		Withdrawn	Adlone Approved Use Unknown

PubMed

Title	Date	PubMed
Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding.	2010-01-22	19895818
A cellular model to monitor proteasome dysfunction by alpha-synuclein.	2009-08-25	19630439
A convenient approach for evaluating the toxicity profiles of in vitro neuroprotective alkylaminophenol derivatives.	2006-03-01	16520231
Synergistic antimalarial activity of ketones with rufigallol and vitamin C.	2005-10	16174410
The neuroprotective activity of 8-alkylamino-1,4-benzoxazine antioxidants.	2001-07-27	11672561
[A case of hepatitis caused by exifone and bezafibrate].	1989-04	2737396
The effects of exifone, a new agent for senile memory disorder, on two models of memory in the mouse.	1987-06	3628440

Patents

Sample Use Guides

In Vivo Use Guide

600 and 1200 mg/d

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:35:26 GMT 2025` Edited by `admin` on `Wed Apr 02 08:35:26 GMT 2025`
Record UNII	38K9TOD4EG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EXIFONE

Official Name

English

exifone [INN]

Preferred Name

English

2,3,3',4,4',5-HEXAHYDROXY-BENZOPHENONE

Systematic Name

English

EXIFONE [MI]

Common Name

English

EXIFONE [MART.]

Common Name

English

NSC-680919

Code

English

Exifone [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1327