TYBAMATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H26N2O4
Molecular Weight	274.3565
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CCCCNC(=O)OCC(C)(CCC)COC(N)=O

InChI

InChIKey=PRBORDFJHHAISJ-UHFFFAOYSA-N

InChI=1S/C13H26N2O4/c1-4-6-8-15-12(17)19-10-13(3,7-5-2)9-18-11(14)16/h4-10H2,1-3H3,(H2,14,16)(H,15,17)

HIDE SMILES / InChI

Molecular Formula	C13H26N2O4
Molecular Weight	274.3565
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Tybamate is a minor tranquilizer that is chemically and pharmacologically related to meprobamate. It is useful in treating anxiety and tension associated with psychoneurotic disorders.

CNS Activity

Originator

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 240	Primary		Approved 8,583	Solacen

C_max

Value	Dose	Co-administered	Analyte	Population
10 μg/mL	15 mg/kg single, oral		TYBAMATE serum	Canis lupus

T_1/2

Value	Dose	Co-administered	Analyte	Population
3 h	15 mg/kg single, oral		TYBAMATE serum	Canis lupus

Doses

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Dose	Population	Adverse events
350 mg 4 times / day steady, oral Highest studied dose	unhealthy, 22 - 41 years
350 mg 3 times / day steady, oral Recommended	unhealthy, 22 - 41 years	Other AEs: Drowsiness, Dizziness...
750 mg 4 times / day steady, oral Highest studied dose	unhealthy, 49.5 years	Other AEs: Tachycardia, Dry mouth...

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AEs

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AE	Significance	Dose	Population
Dizziness	6 patients	350 mg 3 times / day steady, oral Recommended	unhealthy, 22 - 41 years
Drowsiness	7 patients	350 mg 3 times / day steady, oral Recommended	unhealthy, 22 - 41 years
Dry mouth	1 patient	750 mg 4 times / day steady, oral Highest studied dose	unhealthy, 49.5 years
Tachycardia	1 patient	750 mg 4 times / day steady, oral Highest studied dose	unhealthy, 49.5 years

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
001 Chemical	DY554377	https://www.001chemical.com/chem/4268-36-4
ABI Chem	AC1L2FWM
Ambinter	Amb22734893	http://www.ambinter.com/reference/22734893
Aurora Fine Chemicals LLC	A17.944.630	http://online.aurorafinechemicals.com/info?ID=A17.944.630
BOC Sciences	4268-36-4

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PubMed

PubMed

Title	Date	PubMed
No data available in table

Sample Use Guides

In Vivo Use Guide

The usual dose for adults is 0.75 to 2 gm per day. Daily doses larger than 3 gm should not be used.

Route of Administration: Oral

Substance Class	Chemical
Record UNII	3875LLL8M8
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

TYBAMATE

Official Name

English

SOLACEN

Preferred Name

English

W 713

Code

English

Tybamate [WHO-DD]

Common Name

English

2-(Hydroxymethyl)-2-methylpentyl butylcarbamate carbamate

Systematic Name

English

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Classification Tree

Code System

Code

Agent Affecting Nervous System

NCI_THESAURUS

C29756

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Code System

Code

Type

Description

DRUG CENTRAL

2783

PRIMARY

HSDB

3410

PRIMARY

RXCUI

62178

PRIMARY

RxNorm

WIKIPEDIA

Tybamate

PRIMARY

INN

1721

PRIMARY

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Related Record

Type

Details


					3875LLL8M8

TYBAMATE

ACTIVE MOIETY

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SMILES

InChI

CNS Activity

Originator

Approval Year

Conditions

Cmax

T1/2

Doses

AEs

Sourcing

PubMed

Sample Use Guides

C_max

T_1/2