BMS-184476

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C49H55NO14S
Molecular Weight	914.024
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]4(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C5=CC=CC=C5)C6=CC=CC=C6)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@H](C[C@H]7OC[C@@]27OC(C)=O)OCSC)C4(C)C

InChI

InChIKey=UBJAHGAUPNGZFF-XOVTVWCYSA-N

InChI=1S/C49H55NO14S/c1-27-33(62-45(57)38(53)37(30-17-11-8-12-18-30)50-43(55)31-19-13-9-14-20-31)24-49(58)42(63-44(56)32-21-15-10-16-22-32)40-47(6,41(54)39(61-28(2)51)36(27)46(49,4)5)34(60-26-65-7)23-35-48(40,25-59-35)64-29(3)52/h8-22,33-35,37-40,42,53,58H,23-26H2,1-7H3,(H,50,55)/t33-,34-,35+,37-,38+,39+,40-,42-,47+,48-,49+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C49H55NO14S
Molecular Weight	914.024
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15684226 | https://www.ncbi.nlm.nih.gov/pubmed/12901233 | https://adisinsight.springer.com/drugs/800012205

Bristol-Myers Squibb developed BMS-184476 for the potential treatment of solid tumors. BMS-184476 participated in phase II clinical trials for patients with non-small-cell lung cancer, breast, and ovarian cancers. However, that development has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Preclinical antitumor activity of two novel taxanes.	2001	11269747
Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.	2001 Dec 20	11741476
Phase II trial of the novel taxane BMS-184476 as second-line in non-small-cell lung cancer.	2005 Apr	15684226

Sample Use Guides

In Vivo Use Guide

Fifty-six previously treated advanced NSCLC patients received BMS-184476 at a dose of 60 mg/m(2) administered intravenously over 1 h every 21 days.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:34 GMT 2023` Edited by `admin` on `Fri Dec 15 15:55:34 GMT 2023`
Record UNII	3811W2NBZ8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BMS-184476

Common Name

English

PACLITAXEL-7-METHYLTHIOMETHYL ETHER

Common Name

English

7-O-((METHYLTHIO)METHYL)PACLITAXEL

Common Name

English

7-METHYLTHIOMETHYLPACLITAXEL

Common Name

English

7-((METHYLTHIO)METHYL)PACLITAXEL

Common Name

English

7-methylthiomethylpaclitaxel [WHO-DD]

Common Name

English

PACLITAXEL, 7-((METHYLTHIO)METHYL)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67437