ADAMPLATIN-IV

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H17N.2C2H3O2.2Cl.Pt.H3N
Molecular Weight	552.357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

N.[Cl-].[Cl-].[Pt+4].CC([O-])=O.CC([O-])=O.NC12CC3CC(CC(C3)C1)C2

InChI

InChIKey=RGCIZXNKLJAKIS-UHFFFAOYSA-J

InChI=1S/C10H17N.2C2H4O2.2ClH.H3N.Pt/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;2*1-2(3)4;;;;/h7-9H,1-6,11H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4

HIDE SMILES / InChI

Molecular Formula	Cl
Molecular Weight	35.453
Charge	-1
Count	MOL RATIO 2 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H17N
Molecular Weight	151.2487
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Pt
Molecular Weight	195.084
Charge	4
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C2H3O2
Molecular Weight	59.044
Charge	-1
Count	MOL RATIO 2 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H3N
Molecular Weight	17.0305
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	37WM0V5E17
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADAMPLATIN-IV

Common Name

English

LA 12

Preferred Name

English

LA 12 (PLATINUM COMPLEX)

Code

English

PLD-147

Code

English

PLATINUM, BIS(ACETATO-.KAPPA.O)AMMINEDICHLORO(TRICYCLO(3.3.1.13,7)DECAN-1-AMINE)-, (OC-6-43)-

Systematic Name

English

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Code System

Code

Type

Description

CAS

250611-20-2

PRIMARY

PUBCHEM

10007773

PRIMARY

FDA UNII

37WM0V5E17

PRIMARY

SMS_ID

300000041380

PRIMARY

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Related Record

Type

Details


					37WM0V5E17

ADAMPLATIN-IV

ACTIVE MOIETY

Comments:

The results show that deactivation of adamplatin(IV) by sulfur-containing compounds (such as glutathione or metallothioneins) is likely to play a less significant role in the mechanism of resistance of tumor cells to adamplatin(IV) in contrast to the role of these reactions in the effects of cisplatin. Moreover, the treatment of tumor cells with adamplatin(IV) does not result in DNA modifications that would be markedly different from those produced by cisplatin. In contrast, the effects of other factors, such as enhanced accumulation of the drug in cells, strong inhibition of DNA polymerization by these adducts, lowered DNA repair, and DNA-protein cross-linking are different from the effects of these factors in the mechanism underlying activity of cisplatin.

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