FETOXYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C36H36N2O3
Molecular Weight	544.6826
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(OCCOC1=CC=CC=C1)C2(CCN(CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C5=CC=CC=C5

InChI

InChIKey=KISQOVVPIHYLRD-UHFFFAOYSA-N

InChI=1S/C36H36N2O3/c37-29-36(31-15-7-2-8-16-31,32-17-9-3-10-18-32)23-26-38-24-21-35(22-25-38,30-13-5-1-6-14-30)34(39)41-28-27-40-33-19-11-4-12-20-33/h1-20H,21-28H2

HIDE SMILES / InChI

Molecular Formula	C36H36N2O3
Molecular Weight	544.6826
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6502516 | https://books.google.ru/books?id=tsjrCAAAQBAJ&pg=PA120&lpg=PA120&dq=Fetoxylate#v=onepage&q=Fetoxylate&f=false

FETOXYLATE, a phenoxyethyl ester of diphenoxylate, is an opioid receptor agonist. It is used as antidiarrheal.

Approval Year

PubMed

Title	Date	PubMed
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects.	1984 Dec	6502516

Sample Use Guides

In Vitro Use Guide

The antidiarrheal opiates loperamide, fluperamide, diphenoxylate, and fetoxylate inhibited binding of [3H]nitrendipine to membranes from guinea-pig cerebral cortex with Ki values of 0.5 to 10 microM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:54:42 UTC 2023` Edited by `admin` on `Sat Dec 16 16:54:42 UTC 2023`
Record UNII	3791SET69Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FETOXYLATE

Common Name

English

4-PIPERIDINECARBOXYLIC ACID, 1-(3-CYANO-3,3-DIPHENYLPROPYL)-4-PHENYL-, 2-PHENOXYETHYL ESTER

Common Name

English

Fetoxilate [WHO-DD]

Common Name

English

2-PHENOXYETHYL 1-(3-CYANO-3,3-DIPHENYLPROPYL)-4-PHENYLISONIPECOTATE

Systematic Name

English

FETOXILATE

Official Name

English

fetoxilate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C266