AZD-3043

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H29NO5
Molecular Weight	351.4373
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOC(=O)CC1=CC=C(OCC(=O)N(CC)CC)C(OCC)=C1

InChI

InChIKey=QPUVKSKJCNGSGT-UHFFFAOYSA-N

InChI=1S/C19H29NO5/c1-5-11-24-19(22)13-15-9-10-16(17(12-15)23-8-4)25-14-18(21)20(6-2)7-3/h9-10,12H,5-8,11,13-14H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C19H29NO5
Molecular Weight	351.4373
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22531340 | https://adisinsight.springer.com/drugs/800019969 | https://www.marketscreener.com/ASTRAZENECA-9065830/pdf/44790/AstraZeneca_Annual-Report.pdf

AZD-3043, a short-acting intravenous anesthetic/sedative agent. This drug was initially invented by Theravance and then developed by AstraZeneca as a positive allosteric modulator of the γ-aminobutyric acid type A (GABA(A)) receptor containing a metabolically labile ester moiety. Phase I clinical trials for use this compound in anesthesia was completed in Sweden and the UK, but further development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Possible binding sites and interactions of propanidid and AZD3043 within the γ-aminobutyric acid type A receptor (GABA(A)R).	2018 Nov	29125020

Sample Use Guides

In Vivo Use Guide

Fifty-three subjects received AZD3043 in infusion rate cohorts of 1, 3, 6, 12, 18, 27, 36, 54, and 81 mg/kg/h.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:31:47 GMT 2023` Edited by `admin` on `Sat Dec 16 08:31:47 GMT 2023`
Record UNII	372AB76LQL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZD-3043

Code

English

AZD3043

Code

English

BENZENEACETIC ACID, 4-(2-(DIETHYLAMINO)-2-OXOETHOXY)-3-ETHOXY-, PROPYL ESTER

Systematic Name

English

AZD 3043 [WHO-DD]

Common Name

English

(4-((N,N-DIETHYLCARBAMOYL)METHOXY)-3-ETHOXYPHENYL)ACETIC ACID PROPYL ESTER

Systematic Name

English

THRX-918661

Code

English

Code System Code Type Description

FDA UNII

372AB76LQL