Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H11ClN4 |
| Molecular Weight | 294.738 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C2N3C=NN=C3CN=C(C4=CC=CC=C4)C2=C1
InChI
InChIKey=CDCHDCWJMGXXRH-UHFFFAOYSA-N
InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
| Molecular Formula | C16H11ClN4 |
| Molecular Weight | 294.738 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: http://www.drugbank.ca/drugs/DB01215Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/pro/estazolam.html
Sources: http://www.drugbank.ca/drugs/DB01215
Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/pro/estazolam.html
Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Used for the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Marketed under the brand names ProSom, Eurodin.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2093872 Sources: http://www.drugbank.ca/drugs/DB01215 |
|||
Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2890779 |
3.8 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Estazolam Approved UseEstazolam is indicated for the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Launch Date1997 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
54.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
98.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
194 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
180 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
2 mg 2 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
1050 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
2060 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
4343 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
5517 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
2 mg 2 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
14.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
1 mg single, oral dose: 1 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
14.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/1968715/ |
2 mg single, oral dose: 2 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
19 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
4 mg single, oral dose: 4 mg route of administration: Oral experiment type: SINGLE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
17 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/2862746/ |
2 mg 2 times / day steady-state, oral dose: 2 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ESTAZOLAM plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
6 mg 1 times / day single, oral Highest studied dose Dose: 6 mg, 1 times / day Route: oral Route: single Dose: 6 mg, 1 times / day Sources: |
healthy, 21-47 |
|
2 mg 1 times / day multiple, oral Recommended Dose: 2 mg, 1 times / day Route: oral Route: multiple Dose: 2 mg, 1 times / day Sources: |
unhealthy, 42.9 (18-85) Health Status: unhealthy Age Group: 42.9 (18-85) Sex: M+F Sources: |
Disc. AE: Illness, Somnolence... AEs leading to discontinuation/dose reduction: Illness Sources: Somnolence (grade 1-2) Dizziness (grade 1-2) |
40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
Disc. AE: Somnolence, Respiratory depression... AEs leading to discontinuation/dose reduction: Somnolence Sources: Respiratory depression Confusion Coordination impaired Slurred speech Coma |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Illness | Disc. AE | 2 mg 1 times / day multiple, oral Recommended Dose: 2 mg, 1 times / day Route: oral Route: multiple Dose: 2 mg, 1 times / day Sources: |
unhealthy, 42.9 (18-85) Health Status: unhealthy Age Group: 42.9 (18-85) Sex: M+F Sources: |
| Dizziness | grade 1-2 Disc. AE |
2 mg 1 times / day multiple, oral Recommended Dose: 2 mg, 1 times / day Route: oral Route: multiple Dose: 2 mg, 1 times / day Sources: |
unhealthy, 42.9 (18-85) Health Status: unhealthy Age Group: 42.9 (18-85) Sex: M+F Sources: |
| Somnolence | grade 1-2 Disc. AE |
2 mg 1 times / day multiple, oral Recommended Dose: 2 mg, 1 times / day Route: oral Route: multiple Dose: 2 mg, 1 times / day Sources: |
unhealthy, 42.9 (18-85) Health Status: unhealthy Age Group: 42.9 (18-85) Sex: M+F Sources: |
| Coma | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
| Confusion | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
| Coordination impaired | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
| Respiratory depression | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
| Slurred speech | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
| Somnolence | Disc. AE | 40 mg 1 times / day single, oral Overdose Dose: 40 mg, 1 times / day Route: oral Route: single Dose: 40 mg, 1 times / day Sources: |
unknown, unknown Health Status: unknown Age Group: unknown Sex: unknown Sources: |
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
| no | ||||
| no | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
no | |||
| yes [Inhibition 10 uM] | ||||
| yes [Inhibition 10 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/25183402/ |
yes |
Drug as victim
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| no | ||||
| yes |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010-12 |
|
| A validated method for simultaneous screening and quantification of twenty-three benzodiazepines and metabolites plus zopiclone and zaleplone in whole blood by liquid-liquid extraction and ultra-performance liquid chromatography- tandem mass spectrometry. | 2010-07-29 |
|
| Management of tinea capitis in childhood. | 2010-07-14 |
|
| 5-(4-Chloro-phen-yl)-3-(2,4-dimethyl-thiazol-5-yl)-1,2,4-triazolo[3,4-a]isoquinoline. | 2010-04-10 |
|
| [The influence of estazolam on human neurobehavioral function]. | 2010-02 |
|
| [Clinical observation on acupoint catgut embedding at head-acupoint combined with massage of sole for treatment of refractory insomnia]. | 2010-02 |
|
| Four cases of dysthymic disorder and general malaise successfully treated with traditional herbal (kampo) medicines: kamiuntanto. | 2010 |
|
| Algorithms for the assessment and management of insomnia in primary care. | 2009-11-03 |
|
| Drugs associated with more suicidal ideations are also associated with more suicide attempts. | 2009-10-02 |
|
| The XIA's No. 1 sleeping Prescription for the treatment of insomnia of the deficiency type: a clinical observation of 60 cases. | 2009-09 |
|
| [Simultaneous determination of 5 sedative hypnotics in human plasma by reversed phase high-performance liquid chromatography]. | 2009-07 |
|
| Forty cases of insomnia treated by suspended moxibustion at Baihui (GV 20). | 2009-06 |
|
| Simultaneous determination of benzodiazepines and their metabolites in human serum by liquid chromatography-tandem mass spectrometry using a high-resolution octadecyl silica column compatible with aqueous compounds. | 2009-04 |
|
| [Effect of modified xiaoyao powder for improving sleep in patients with psychological stress insomnia]. | 2009-03 |
|
| [Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam]. | 2009-03 |
|
| Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders. | 2009 |
|
| Auricular acupuncture for insomnia: a systematic review. | 2008-11 |
|
| High performance liquid chromatography-tandem mass spectrometric determination of rupatadine in human plasma and its pharmacokinetics. | 2008-08-05 |
|
| Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry. | 2008-07 |
|
| Long-term stability of various drugs and metabolites in urine, and preventive measures against their decomposition with special attention to filtration sterilization. | 2008-01-30 |
|
| Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. | 2008 |
|
| Abdominal acupuncture for insomnia in women: a randomized controlled clinical trial. | 2008 |
|
| Indiplon in the treatment of sleep disorders. | 2007-12 |
|
| [Randomized and controlled study on effect of acupuncture on sleep quality in the patient of primary insomnia]. | 2007-12 |
|
| Sensitive and selective liquid chromatography-tandem mass spectrometry method for the quantification of aniracetam in human plasma. | 2007-10-15 |
|
| High performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI) method for simultaneous determination of venlafaxine and its three metabolites in human plasma. | 2007-05-01 |
|
| [Comparative study on treatment of somnipathy in patients with hypertension by traditional Chinese medicine and by estazolam]. | 2007-02 |
|
| Determination of four benzodiazepine residues in pork using multiwalled carbon nanotube solid-phase extraction and gas chromatography-mass spectrometry. | 2006-12-08 |
|
| [Analysis of 37 drugs in whole blood by HPLC after solid phase extraction]. | 2006-10-15 |
|
| [Effects of midazolam and estazolam as hypnotics in hypertensive patients with chronic insomnia: a multicentre, open labeled, randomized clinical trial]. | 2006-04 |
|
| Simultaneous determination of spironolactone and its active metabolite canrenone in human plasma by HPLC-APCI-MS. | 2006-04 |
|
| Sleep maintenance insomnia: strengths and weaknesses of current pharmacologic therapies. | 2006-03-07 |
|
| High-performance liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry determination of zaleplon in human plasma. | 2006-02-24 |
|
| Safety and tolerability of oral antifungal agents in the treatment of fungal nail disease: a proven reality. | 2005-12 |
|
| Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists. | 2005-06-15 |
|
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | 2005-06 |
|
| Identification of human cytochrome P450 enzymes involved in the formation of 4-hydroxyestazolam from estazolam. | 2005-05 |
|
| TCM treatment for 63 cases of senile dyssomnia. | 2005-03 |
|
| Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds. | 2005 |
|
| Date-rape drugs scene in Poland. | 2005 |
|
| Simultaneous determination of albendazole and its major active metabolite in human plasma using a sensitive and specific liquid chromatographic-tandem mass spectrometric method. | 2004-06-29 |
|
| Overview of the therapeutic management of insomnia with zolpidem. | 2004 |
|
| Pharmacokinetics and drug interactions of the sedative hypnotics. | 2003 |
|
| Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug. | 2002-03 |
|
| Metabolic alkalosis and myoclonus from antacid ingestion. | 1996-06 |
|
| Estazolam treatment of insomnia in generalized anxiety disorder: a placebo-controlled study. | 1991-08 |
|
| Inhibition of the binding and the behavioral effects of thyrotropin-releasing hormone (TRH) by the triazolobenzodiazepines. | 1988-05 |
|
| [Electroencephalographic effects of 450191-S and its metabolites in rabbits with chronic electrode implants]. | 1986-07 |
|
| Comparative efficacy of estazolam, flurazepam, and placebo in outpatients with insomnia. | 1986-07 |
|
| Diazepam-induced decrease in histamine turnover in mouse brain. | 1986-05-27 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/pro/estazolam.html
Usual Adult Dose for Insomnia
1 to 2 mg orally at bedtime
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2890779
Incubation of rabbit PRP with etizolam for 2 min before administration of aggregating agents inhibited aggregation induced by PAF (190 nM) with
an IC50 of 3.8 uM. Etizolam at a higher concentration (300 uM) only slightly in
hibited ADP (15 uM) and arachidonic acid-induced aggregation
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:56:07 GMT 2025
by
admin
on
Mon Mar 31 17:56:07 GMT 2025
|
| Record UNII |
36S3EQV54C
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C1012
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
WHO-ATC |
N05CD04
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
NDF-RT |
N0000007542
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
LIVERTOX |
NBK548660
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
WHO-VATC |
QN05CD04
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
NDF-RT |
N0000175694
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
||
|
DEA NO. |
2756
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C47520
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
D004949
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
CC-24
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
3261
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
36S3EQV54C
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
SUB07241MIG
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
1056
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
1249905
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
7550
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
4077
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | RxNorm | ||
|
Estazolam
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
DB01215
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
100000082361
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
ESTAZOLAM
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
CHEMBL285674
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
36S3EQV54C
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
3611
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
249-982-4
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
m5027
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | Merck Index | ||
|
DTXSID5020572
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
290818
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
4858
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY | |||
|
29975-16-4
Created by
admin on Mon Mar 31 17:56:07 GMT 2025 , Edited by admin on Mon Mar 31 17:56:07 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
BASIS OF STRENGTH->SUBSTANCE |
ASSAY (HPLC)
USP
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
METABOLITE LESS ACTIVE -> PARENT |
m. 1-0x0-estazolam was about five times less effective than the parent drug
in terms of brain concn. necessary to disrupt rota-rod performance but only twice in
respect to the anticonvulsant activity.
|
||
|
|
METABOLITE -> PARENT | |||
|
|
METABOLITE -> PARENT | |||
|
|
METABOLITE -> PARENT | |||
|
|
METABOLITE -> PARENT | |||
|
|
METABOLITE -> PARENT |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
|
IMPURITY -> PARENT | |||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |