Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C16H21NO3.ClH |
| Molecular Weight | 311.804 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3
InChI
InChIKey=FRMDDIJBLQNNTC-RDYJJYPNSA-N
InChI=1S/C16H21NO3.ClH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.3428 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date1983 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bilateral panuveitis in a child with hypohidrotic ectodermal dysplasia. | 2002 Sep |
|
| Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. | 2003 Jan |
|
| Familial HLA-A2- and HLA-B7-associated anterior uveitis. | 2004 Oct |
|
| Acute posterior multifocal placoid pigment epitheliopathy after meningococcal C conjugate vaccine. | 2005 Apr |
|
| Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration? | 2005 Mar |
|
| Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. | 2005 Nov |
|
| Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. | 2006 Dec |
|
| Homatropine and psychosis in Weill-Marchesani syndrome. | 2006 Jul |
|
| Efficacy of trypan blue in posterior capsulorhexis with optic capture in pediatric cataracts [ISRCTN48221688]. | 2006 Mar 16 |
|
| [Neurotoxic effects induced by the topical administration of cycloplegics. A case report and review of the literature]. | 2006 Nov 16-30 |
|
| Pretreating rats with parenteral ophthalmic antimuscarinic agents decreases mortality from lethal organophosphate poisoning. | 2007 Apr |
|
| Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography. | 2007 Aug |
|
| True moving bed electrophoresis using stepped electric field gradients. | 2007 May |
|
| Granuloma annulare anterior uveitis. | 2008 Jan-Feb |
|
| Managing corneal disease: focus on suppurative keratitis. | 2009 Dec |
|
| Syphilitic palmoplantar keratoderma and ocular disease: a rare combination in an HIV-positive patient. | 2009 Dec |
|
| Two differing presentations of chronic bilateral anterior uveitis. | 2009 Feb |
|
| Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle. | 2010 Jul |
|
| Acute postoperative endophthalmitis by Gemella haemolysans. | 2010 May-Jun |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
|
| Efficacy assessment of various anticholinergic agents against topical sarin-induced miosis and visual impairment in rats. | 2012 Apr |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:34:13 GMT 2023
by
admin
on
Fri Dec 15 17:34:13 GMT 2023
|
| Record UNII |
365MO3S3N9
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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100000086686
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211-280-0
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637-21-8
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SUB02531MIG
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m6038
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DTXSID10858796
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365MO3S3N9
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admin on Fri Dec 15 17:34:13 GMT 2023 , Edited by admin on Fri Dec 15 17:34:13 GMT 2023
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|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
