Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C16H21NO3.ClH |
| Molecular Weight | 311.804 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3
InChI
InChIKey=FRMDDIJBLQNNTC-RDYJJYPNSA-N
InChI=1S/C16H21NO3.ClH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C16H21NO3 |
| Molecular Weight | 275.3428 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date4.15497585E11 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. | 2002 Mar |
|
| Bilateral panuveitis in a child with hypohidrotic ectodermal dysplasia. | 2002 Sep |
|
| Microbial keratitis and vision loss with contact lenses. | 2003 Jan |
|
| Dense membrane formation after combined phacoemulsification-trabeculectomy surgery. | 2005 Jun |
|
| Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. | 2006 Dec |
|
| [Neurotoxic effects induced by the topical administration of cycloplegics. A case report and review of the literature]. | 2006 Nov 16-30 |
|
| Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography. | 2007 Aug |
|
| Increasing the scale of true moving bed electrophoretic separations using filtration to reduce solvent volumetric flows between sections II and III. | 2007 Jan 5 |
|
| Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants. | 2008 |
|
| Hypotony maculopathy in a patient with HLA-B27-associated uveitis. | 2008 May-Jun |
|
| Voriconazole for the treatment of refractory Aspergillus fumigatus keratitis. | 2008 May-Jun |
|
| First aid for complications of infectious keratitis. | 2008 May-Jun |
|
| Two differing presentations of chronic bilateral anterior uveitis. | 2009 Feb |
|
| Keratouveitis caused by Euphorbia plant sap. | 2009 Jul-Aug |
|
| Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats. | 2009 May |
|
| Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
|
| LC-ESI MS/MS quantification of atropine and six other antimuscarinic tropane alkaloids in plasma. | 2010 Jan |
|
| Current approach in the diagnosis and management of panuveitis. | 2010 Jan-Feb |
|
| Acute postoperative endophthalmitis by Gemella haemolysans. | 2010 May-Jun |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
|
| Efficacy assessment of various anticholinergic agents against topical sarin-induced miosis and visual impairment in rats. | 2012 Apr |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 22:30:26 UTC 2022
by
admin
on
Fri Dec 16 22:30:26 UTC 2022
|
| Record UNII |
365MO3S3N9
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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211-280-0
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637-21-8
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SUB02531MIG
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M6038
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admin on Fri Dec 16 22:30:26 UTC 2022 , Edited by admin on Fri Dec 16 22:30:26 UTC 2022
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PRIMARY | Merck Index | ||
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DTXSID10858796
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admin on Fri Dec 16 22:30:26 UTC 2022 , Edited by admin on Fri Dec 16 22:30:26 UTC 2022
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365MO3S3N9
Created by
admin on Fri Dec 16 22:30:26 UTC 2022 , Edited by admin on Fri Dec 16 22:30:26 UTC 2022
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
