Details
Stereochemistry | ACHIRAL |
Molecular Formula | C18H32Br2N4O2 |
Molecular Weight | 496.28 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 2 |
SHOW SMILES / InChI
SMILES
BrCCC(=O)N1CC[N+]2(CC1)CC[N+]3(CCN(CC3)C(=O)CCBr)CC2
InChI
InChIKey=JXEICPOBKSQAIU-UHFFFAOYSA-N
InChI=1S/C18H32Br2N4O2/c19-3-1-17(25)21-5-9-23(10-6-21)13-15-24(16-14-23)11-7-22(8-12-24)18(26)2-4-20/h1-16H2/q+2
Molecular Formula | C18H32Br2N4O2 |
Molecular Weight | 496.28 |
Charge | 2 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Dibrospidium (Spyrobromin) is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correlate with spirobromine antitumor activity. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. Spyrobromin can diminish the latent period of the development of tumours in the experimental rats at intraperitoneal administration. At intragastric administration of the drug no decrease was noted in the latent period and no increase of tumours was observed in the experimental groups of the animals as compared with control. Dibrospidium has been examined for the treatment of bone cancer. The oral route of administration is the most safe with respect to the oncogenic risk. It was noted that spirobromin exerted the most pronounced toxic action on erythrocytes. Dibrospidium is used for the treatment of acute leukemias (mainly in combination therapy), malignant lymphomas, laryngeal cancer and skin reticulosis.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:42:02 GMT 2023
by
admin
on
Sat Dec 16 05:42:02 GMT 2023
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Record UNII |
34R8M96SDC
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Record Status |
Validated (UNII)
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Record Version |
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-
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72115
Created by
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34R8M96SDC
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DTXSID40235738
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admin on Sat Dec 16 05:42:02 GMT 2023 , Edited by admin on Sat Dec 16 05:42:02 GMT 2023
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86641-78-3
Created by
admin on Sat Dec 16 05:42:02 GMT 2023 , Edited by admin on Sat Dec 16 05:42:02 GMT 2023
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