PALIRODEN FUMARATE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H24F3N.C4H4O4
Molecular Weight	523.5428
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.FC(F)(F)C1=CC=CC(=C1)C2=CCN(CCC3=CC=C(C=C3)C4=CC=CC=C4)CC2

InChI

InChIKey=CNKDAIHKQGBZGJ-WLHGVMLRSA-N

InChI=1S/C26H24F3N.C4H4O4/c27-26(28,29)25-8-4-7-24(19-25)23-14-17-30(18-15-23)16-13-20-9-11-22(12-10-20)21-5-2-1-3-6-21;5-3(6)1-2-4(7)8/h1-12,14,19H,13,15-18H2;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C26H24F3N
Molecular Weight	407.4707
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800013042 | https://www.ncbi.nlm.nih.gov/pubmed/16472201 | https://clinicaltrials.gov/ct2/show/NCT00220272 | https://clinicaltrials.gov/ct2/show/NCT00285025 | https://www.thepharmaletter.com/article/sanofi-aventis-to-file-31-ndas-by-end-2010-with-10-likely-blockbuster-drugs

Paliroden is an orally active drug that activates the synthesis of endogenous neurotrophins or nerve growth factors. Paliroden was investigated in phase II clinical trial in patients with Alzheimer's disease and to evaluate its effect on 18F-Dopa PET imaging in patients with Parkinson's disease. The further development of paliroden was discontinued due to its insufficient efficacy.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of paliroden (SR57667B) and xaliproden on adult brain neurogenesis.	2006-02	16472201

Sample Use Guides

In Vivo Use Guide

The primary objective is to study the effect of SR57667B (PALIRODEN) at the dose of 4 mg/d on progression of dopaminergic nigro-striatal lesions assessed by 18F-Dopa PET imaging.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 20:31:56 GMT 2025` Edited by `admin` on `Wed Apr 02 20:31:56 GMT 2025`
Record UNII	34PAS3CUV2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SR57667B FUMARATE SALT

Preferred Name

English

PALIRODEN FUMARATE

Common Name

English

Pyridine, 1-(2-[1,1?-biphenyl]-4-ylethyl)-1,2,3,6-tetrahydro-4-[3-(trifluoromethyl)phenyl]-, fumarate

Systematic Name

English

Code System Code Type Description

FDA UNII

34PAS3CUV2

Created by admin on Wed Apr 02 20:31:56 GMT 2025 , Edited by admin on Wed Apr 02 20:31:56 GMT 2025

PRIMARY

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