SIMENDAN

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C14H12N6O
Molecular Weight	280.2847
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CC(=O)NN=C1C2=CC=C(NN=C(C#N)C#N)C=C2

InChI

InChIKey=WHXMKTBCFHIYNQ-UHFFFAOYSA-N

InChI=1S/C14H12N6O/c1-9-6-13(21)19-20-14(9)10-2-4-11(5-3-10)17-18-12(7-15)8-16/h2-5,9,17H,6H2,1H3,(H,19,21)

HIDE SMILES / InChI

Molecular Formula	C14H12N6O
Molecular Weight	280.2847
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Approval Year

PubMed

Title	Date	PubMed
Levosimendan: A promising agent for the treatment of hospitalized patients with decompensated heart failure.	2000 May	10980898
Myocardial efficiency during levosimendan infusion in congestive heart failure.	2000 Nov	11103755
Levosimendan.	2001	11368286
Levosimendan: a parenteral calcium-sensitising drug with additional vasodilatory properties.	2001 May	11322869
Levosimendan: a new dual-action drug in the treatment of acute heart failure.	2003 Jun	12846347
Levosimendan in patients with low-output heart failure: lessons from the LIDO trial.	2003 May	14635368
Is calcium sensitization the best strategy to improve myocardial contractility in acute heart failure?	2003 May	14635367
The use of the novel calcium sensitizer levosimendan in critically ill patients.	2004 Aug	15675206
Treatment of acute heart failure in an infant after cardiac surgery using levosimendan.	2004 Jul	15201012
Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators.	2004 Nov	15489122
Levosimendan: a calcium-sensitizing agent for the treatment of patients with decompensated heart failure.	2004 Sep	16036037
Short-term effects of levosimendan and prostaglandin E1 on hemodynamic parameters and B-type natriuretic peptide levels in patients with decompensated chronic heart failure.	2005 Dec	16084762
[Levosimendan, a revolution in the world of inotropic agents?].	2005 May 25	15997981
Levosimendan improves postresuscitation outcomes in a rat model of CPR.	2005 Nov	16242524
Treatment of cardiogenic shock with levosimendan in combination with beta-adrenergic antagonists.	2005 Nov	16143579
Pharmacology of new agents for acute heart failure syndromes.	2005 Sep 19	16181825
The utility of levosimendan in the treatment of heart failure.	2007	17364447
The use of levosimendan in comparison and in combination with dobutamine in the treatment of decompensated heart failure.	2007 Apr	17376021
Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats.	2007 Apr	17325658
Right ventricular dysfunction.	2007 Oct	17762232
The cardioprotective effects of levosimendan: preclinical and clinical evidence.	2007 Sep	17878752
Levosimendan: from basic science to clinical practice.	2009 Dec	19101796
Effects of levosimendan in experimental acute coxsackievirus myocarditis.	2009 Oct	19772522
Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure.	2010 Oct	20811386
Acetylation status does not affect levosimendan's hemodynamic effects in heart failure patients.	2011 Apr	21133820
The protective effects of levosimendan on ischemia/reperfusion injury and apoptosis.	2011 Jan	21208156
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.	2013 Dec	24052561

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:19:46 GMT 2023` Edited by `admin` on `Sat Dec 16 16:19:46 GMT 2023`
Record UNII	349552KRHK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SIMENDAN

Official Name

English

PROPANEDINITRILE, ((4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL)HYDRAZONO)-

Systematic Name

English

simendan [INN]

Common Name

English

2-(2-(4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL)HYDRAZINYLIDENE)PROPANEDINITRILE

Systematic Name

English

MESOXALONITRILE (±)-(P-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL)HYDRAZONE

Common Name

English

PROPANEDINITRILE, 2-(2-(4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL)HYDRAZINYLIDENE)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78322