ACEGLATONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H10O8
Molecular Weight	258.1816
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12OC(=O)[C@@H](OC(C)=O)[C@@]1([H])OC(=O)[C@@H]2OC(C)=O

InChI

InChIKey=ZOZKYEHVNDEUCO-DKXJUACHSA-N

InChI=1S/C10H10O8/c1-3(11)15-7-5-6(18-9(7)13)8(10(14)17-5)16-4(2)12/h5-8H,1-2H3/t5-,6-,7-,8+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C10H10O8
Molecular Weight	258.1816
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/1546564
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/6614934

Aceglatone (Glucaron/ 2.5-Di-O-acetyl-D-glucaro-1,4:6,3-dilactone/ DAGDL ) is a non-toxic natural inhibitor of beta-glucuronidase. Is an antineoplastic drug available in Japan, which is used for preventive therapy after preservative operation against bladder cancer.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-glucuronidase 13 Target ID: CHEMBL2728 Sources: http://www.ncbi.nlm.nih.gov/pubmed/3091283	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bladder cancer 16 Sources: http://www.ncbi.nlm.nih.gov/pubmed/1546564	Preventing		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Enhancement by phenothiazine and 2,5-di-O-acetyl-D-glucosaccharo-(1,4)(6,3)-dilactone of bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in rats.	1984 Aug	6548659

Patents

Sample Use Guides

In Vivo Use Guide

aceglatone 2.25 g/day for three doses

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:46:14 GMT 2023` Edited by `admin` on `Sat Dec 16 16:46:14 GMT 2023`
Record UNII	347Q3OOJ13
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACEGLATONE

Official Name

English

2,5-DI-O-ACETYL-D-GLUCARO-1,4:6,3-DILACTONE

Common Name

English

D-GLUCARIC ACID 1,4:6,3-DILACTONE DIACETATE

Common Name

English

aceglatone [INN]

Common Name

English

2,5-DI-O-ACETYL-D-GLUCOSACCHARO-1,4:6,3-DILACTONE

Common Name

English

ACEGLATONE [JAN]

Common Name

English

Aceglatone [WHO-DD]

Common Name

English

GLUCARON

Brand Name

English

ACEGLATONE [MI]

Common Name

English

ACEGLATONE [MART.]

Common Name

English

D-GLUCARIC ACID DI-.GAMMA.-LACTONE DIACETATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1017