NICOCORTONIDE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C31H37NO7
Molecular Weight	535.628
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 8
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@]4(C)[C@]5(CC[C@@]24OC(O5)\C=C/C)C(=O)COC(=O)C6=CC=NC=C6

InChI

InChIKey=LZHLAFIPUJPCBN-ZTOAAZPKSA-N

InChI=1S/C31H37NO7/c1-4-5-25-38-30-12-13-31(39-25,24(35)18-37-27(36)19-9-14-32-15-10-19)29(30,3)17-23(34)26-22(30)7-6-20-16-21(33)8-11-28(20,26)2/h4-5,9-10,14-16,22-23,25-26,34H,6-8,11-13,17-18H2,1-3H3/b5-4-/t22-,23+,25?,26-,28+,29+,30-,31+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C31H37NO7
Molecular Weight	535.628
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	6 / 8
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7426413 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y

Nicocortonide is an anti-inflammatory corticosteroid for topical use.

Approval Year

PubMed

Title	Date	PubMed
Effect of five anti-inflammatory steroids on collagen and glycoaminoglycan synthessis in vitro.	1980 Aug	7426413

Sample Use Guides

In Vitro Use Guide

At concentration 10(-9) M nicocortonide inhibited synthesis of hyaluronic acid by 23%. An inhibition of collagen synthesis was obtained with nicocortonide only at the highest studied concentration: 1 x 10(-4) M. The synthesis of sulphated glycosaminoglycans was inhibited (by 30- 35%) at the highest steroid concentration tested (1 x 10(-5) M).

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:18 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:18 GMT 2023`
Record UNII	341BNG318Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICOCORTONIDE

Official Name

English

nicocortonide [INN]

Common Name

English

11.BETA.,14,17,21-TETRAHYDROXYPREGN-4-ENE-3,20-DIONE CYCLIC 14,17-ACETAL WITH CROTONALDEHYDE, 21-ISONICOTINATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521